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The Sedar, formulation of this investigation is a composition of natural ingredients, which has a relaxant, anxiolytic, and sleep-inducing action. The active ingredients of the formulations are melatonin, L-tryptophan (an important amino acid, which is converted in the brain to serotonin (neurotransmitter that contributes to normal sleep cycle); serotonin is sequentially converted to Melatonin), Pasiflora, valeriana, hawthorn and escholtsia increase GABA levels in the brain. The aim of this investigation is to study the release profile of melatonin from the tablets of the above formulation. This formulation is a unique food supplement, which offers numerous advantages including sleep onset dysfunctions. Tablets' uniformity (in terms of weight and thickness) was achieved and the disintegration time as well as the dissolution profile matched the requirements for immediate release formulations. Tablet formulations are also required to be hard enough such that they do not break up in the packaging (bottle or blister container) but also friable enough to disintegrate in the gastrointestinal tract. The tablets' strength (in terms of friability and hardness) as a consequence of the choice of the appropriate type, but also the quantity of excipients in the tablet formulation, along with the application of the suitable compression force, was evaluated ensuring right handling/packaging, safe transportation and facile release in the gastrointestinal environment.

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