No abstract

A 34‐year‐old woman presented due to progressive painful swelling around the nail of the right index finger. Onychectomy and drainage of the abscess of the affected finger were performed as the inflammation was progressive despite the previous antibiotic therapy. The microbiological culture revealed a ciprofloxacin‐susceptible Citrobacter braakii.

Introduction: Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and adolescents. Spindle cell RMS is a rare variant of embryonal RMS that has a predilection for young males. Aim: We are presenting here a case of a local recurrence of an embryonal variant of the spindle cell RMS in a 19-year-old male. Case report: In this report it is described the study of patient with local recurrence of spindle cell embryonal RMS of the left testis after left orchiectomy and adjuvant chemotherapy. Computed tomography of the abdomen was used to evaluate the tumor. The recurrent mass was about 7,5cm and the patient was operated and discharged after 6 days in a good condition. Six months after the operation the patient had a new recurrence of RMS in the left retroperitoneal space. Conclusion: RMS is a malignant tumor of mesenchymal origin that is treated by a combination of surgery, chemotherapy, and radiation. However, up to one-third of patients experience recurrence.

Background Knee osteoarthritis is a disease linked to severe pain and disability and several methods have been used to aid alleviate its symptoms, with varying degrees of success. Cooled radiofrequency ablation (CRFA) and cryoneurolysis (CRYON) are two novel methods under investigation for their capacity to control pain in knee osteoarthritis, while keeping a low complication rate. In this study the two methods will be compared with sham surgery, giving us an opportunity to compare their results. Methods In this prospective, randomized, sham-controlled, double-blind trial 60 patients suffering from knee osteoarthritis will be recruited using a diagnostic block of the genicular nerves under ultrasound guidance. Three groups will be created: cooled radiofrequency ablation group (24 patients), cryoneurolysis group (24 patients) and sham group (12 patients), through software randomization. Target of the interventions will be the three main genicular nerves; superior medial, superior lateral and inferior medial as well as the suprapatellar branch. The primary objective of this clinical trial is to evaluate the efficacy of CRFA or CRYON in comparison to sham surgery at 2-, 4-, 12- and 24-weeks post intervention using the Numerical Rating Pain Scale. Secondary objectives will be the safety of the 2 main techniques, as well as the clinical outcomes at 12- and 24-weeks post intervention using the Knee Injury and Osteoarthritis Outcome Score, the Oxford Knee Score and the 7-point scale of Patient Global Impression of Change. Discussion These two novel techniques are able to block the pain transmission through the genicular nerves via different ways. In contrast to cryoneurolysis treatment, where the literature is scarce, the method of CRFA has been well documented in the past. This will be the first clinical trial to compare them to sham surgery and draw conclusions about their safety and efficacy. The main genicular nerves as targets for cryoneurolysis will also be utilized for the first time. The institutional review board (IRB) of our University Hospital has approved the study (11846/05/10/2021) and written informed consent from participating patients would be obtained. Trial registration ISRCTN87455770 https://doi.org/10.1186/ISRCTN87455770

No abstract