Background: Vitiligo is an acquired disorder characterized by well circumscribed depigmented macules and patches that result from a progressive loss of functional melanocytes. In India and perhaps elsewhere also patients with vitiligo have severe psychological and social problems. Quality of life is multidimensional index of different social, behavioural and cultural factors. Different tools were developed for measuring quality of life focusing on different conditions and diseases. The dermatology life quality index (DLQI) questionnaire is designed for use in patients of age more than 16. It can be used to measure the impact of vitiligo on quality of life. To assess the dermatology specific quality of life in patients with vitiligo. To study impact of vitiligo on their quality of life. Methods: In this study 150 patients diagnosed with vitiligo during a 1-year period were included. DLQI was calculated for every patient. Results: The mean DLQI score in our study was 6.14. There was a statistically significant difference in mean DLQI of unmarried as compared to married. There were no statically significant differences in other groups. Out of 150 patients of vitiligo, 3 (2%) patients had no effect, 66 (44%) patients had small effect, 69 (46%) patients have moderate effect, while 12 (8%) patient had very large effect of vitiligo on their quality of life. Conclusions: Vitiligo affects quality of life in majority of patients. So, it should be treated aggressively with various treatment modality along with proper counselling and psychological support.

<p class="abstract"><strong>Background:</strong> There is a vast spectrum of disorders with basic defect in the process of keratinization. There are various associations (genetic, autoimmune and environmental) with different keratinization disorders. The aims and objectives of this study to study the epidemiology, clinical features and associations in various keratinization disorders.   </p><p class="abstract"><strong>Methods:</strong> A retrospective observational study of 500 patients was done in a tertiary care center. Detailed history was taken and clinical examination was done. Investigations and skin biopsy were performed when needed.<strong></strong></p><p class="abstract"><strong>Results:</strong> In our study of 500 cases of keratinizing disorders, there were 269 (53.8%) cases of psoriasis, 132 (26.4%) cases of  palmoplantar keratoderma, 22 (4%) cases of phrynoderma, 19 (3.8%) cases of ichthyosis, 13 (2.6%) cases of acanthosis nigricans, 11 (2.2%) cases of porokeratosis, 7 (1.4%) cases of Darier’s disease, 3 (0.6%) Cases of pityriasis rubra pilaris, 2 (0.4%) cases each of pachyonychia congenita and erythron keratoderma. The most common age group affected was 51-60 years (19.6%). Males to female ratio was 1.13:1. Chronic plaque psoriasis (43.51%) was the most common variant of psoriasis. Psoriasis vulgaris (75%) was the most common cause of erythroderma. Histopathological findings in all patients whose biopsy was taken was consistent with clinical diagnosis. Non trans gradient (97.75%) was the most common type of palmoplantar keratoderma. Ichthyosis vulgaris (47.38%) was the most common type of ichthyosis.</p><p class="abstract"><strong>Conclusions:</strong> Heredity plays an important role in keratinization disorders. Also, various comorbidities have been associated with different keratinization disorders. Hence, we need to look for these factors while evaluating the patients of keratinization disorders.</p>