The advancements in various technologies have changed the way various industries approach their work and also the way they took corrective steps for betterment in their routine work. The healthcare industry is also one of the adopters of innovative technologies. In recent times, artificial intelligence and its counterpart machine leaning becomes a vital part of healthcare industry which may handle new medical procedures and effective maintenance of patient data. Such advanced technology like machine leaning has a huge trend in the industry and is widely used in many applications. Pattern discovery from versatile medical data sources, prediction of diseases, drug reaction and applications, etc. are the major applications of machine learning in the healthcare domain. Such unprecedented opportunities in the healthcare domain are available because of the explosive growth of health-related data. The chapter will highlight the various applications and techniques of machine leaning in the field of healthcare. It will bridge the gap between available data and effective implementation.