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We report a series of new heterocyclic compounds containing the imidazole scaffold were synthesized such as 2-(furan-2-yl)-1-(piperidine-4-yl)-1H-benzo[d]imidazole derivative. Due to the biological activities of imidazole as antimicrobial agents, in the present work, all the synthesized compounds were characterized by 1 H NMR and LC-MS analysis and some of the compounds are characterized by 13 C NMR. All the synthesized compounds were evaluated for their antimicrobial activity against Gram +ve and Gram -ve bacteria and different fungal species which demonstrated good to moderate antimicrobial activity, in which compounds 7b and 7l shows highest antimicrobial activity.

We report a new method for the efficient and rapid synthesis of (2-butyl-5-nitrobenzo[b]furan-3-yl)[4-(substituted ethynyl)phenyl]methanones using a Pd-Cu catalyzed microwave-assisted Sonogashira coupling reaction. In comparison to the conventional heating procedure, the time of synthesis and effort are significantly reduced in the present method, without side-product formation. Microwave irradiation considerably accelerated the formation of (2-butyl-5-nitrobenzo[b]furan-3-yl)[4-(substituted ethynyl)phenyl]methanone analogues.

We report here the synthesis of different substituted tetrahydropyridopyrazine derivatives. This approach of synthesis has been designed in a way that in first simple chloro-amine coupling as an alternative of Buchwald coupling followed by heterogeneous hydrogenation of nitro to give amine and further cyclization of this amine with carboxylic acid was accomplished in a single process with the help of continuous flow hydrogenation reactor. This processing was a generation of hydrogen (in situ) by electrolysis of water molecule and using a prepacked cartridge of a palladium catalyst. In a further step, LAH was used to reduce lactam to a yielding product as tetrahydropyridopyrazine (TPP) scaffold. Final adducts were obtained using substituted benzoyl and sulfonyl derivatives.