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Motor performance declines with normal aging. Previous neuroimaging work revealed aging-related general increases in neural activity, especially in the prefrontal and pre-motor areas, associated with a loss of hemispheric lateralization. However, the functional mechanisms underlying these changes and their relation to aging-associated motor decline to date remain elusive. To further elucidate the neural processes underlying aging-related motor decline, we recorded EEG from younger and older subjects while they performed a finger-tapping task. As a measure of synchronization between motor areas, we computed the inter-regional phase-locking value which reflects functional connectivity between distinct neural populations. Behavioral data revealed increased movement times in older subjects. EEG data showed that phase locking in the δ-θ frequencies is a general, age-independent phenomenon underlying the execution of simple finger movements. In stark contrast, the extent of synchronization between motor areas significantly differed dependent upon age of subjects: multiple additional intra- and inter-hemispheric connections were observed in older subjects. Our data shed light upon the results of previous neuroimaging studies showing aging-related increases in neural activation. In particular, data suggest that the observed aging-dependent substantial intra- and inter-hemispheric reorganization of connectivity between the corresponding motor areas underlies the previously reported loss of lateralization in older subjects. The changes observed are likely to represent compensatory mechanisms aiming at preserved task performance in older subjects.

With increasing age cognitive performance slows down. This includes cognitive processes essential for motor performance. Additionally, performance of motor tasks becomes less accurate. The objective of the present study was to identify general neural correlates underlying age-related behavioral slowing and the reduction in motor task accuracy. To this end, we continuously recorded EEG activity from 18 younger and 24 older right-handed healthy participants while they were performing a simple finger tapping task. We analyzed the EEG records with respect to local changes in amplitude (power spectrum) as well as phase locking between the two age groups. We found differences between younger and older subjects in the amplitude of post-movement synchronization in the β band of the sensory-motor and medial prefrontal cortex (mPFC). This post-movement β amplitude was significantly reduced in older subjects. Moreover, it positively correlated with the accuracy with which subjects performed the motor task at the electrode FCz, which detects activity of the mPFC and the supplementary motor area. In contrast, we found no correlation between the accurate timing of local neural activity, i.e. phase locking in the δ-θ frequency band, with the reaction and movement time or the accuracy with which the motor task was performed. Our results show that only post-movement β amplitude and not δ-θ phase locking is involved in the control of movement accuracy. The decreased post-movement β amplitude in the mPFC of older subjects hints at an impaired deactivation of this area, which may affect the cognitive control of stimulus-induced motor tasks and thereby motor output.

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