Objective Oral lichen planus (OLP) is a usual chronic inflammatory disease of the oral mucosa with malignant capacity, whose pathogenesis is not yet well known. Free radicals and reactive oxygen species may have a vital role in the pathogenesis of oral lichen planus. This study aimed to assess Glutathione reductase, catalase, and free thiol levels in the saliva of OLP patients and compare it with healthy people. Methods In this cross-sectional study, 35 patients with OLP and 20 healthy people were involved. Five mL of whole, unstimulated saliva samples were collected in the morning, and the salivary levels of antioxidants were measured by ELISA technique. In this experiment, sex, age and OLP types were also evaluated. Results There was a significant decrease in the patients’ salivary level of Glutathione reductase (0.2043 mU/ml in patients and 0.3901 mU/ml in the control group) and catalase (0.1525 mU/ml in patients and 0.2700 mU/ml in the control group) (p = 0.001). But there were no differences between the two groups regarding free-thiol levels (0.0586 mU/ml in patients and 0.0569 mU/ml in the control group) (p = 0.7). However, there was no correlation between age and gender with the antioxidants’ contents. There was a significant decrease in glutathione reductase and catalase in the erosive type than in the non-erosive type. Conclusions In this study, we found that the salivary levels of Glutathione reductase and Catalase were lower in OLP patients than in the healthy group, which means these antioxidants were affected by OLP and also associated with the type of it. So salivary Glutathione reductase and Catalase levels may be used as biomarkers for OLP monitoring and treatment.

Objective: Oral lichen planus (OLP) is a usual chronic inflammatory disease of the oral mucosa with malignant capacity, whose pathogenesis is not yet well known. Free radicals and reactive oxygen species may have a vital role in the pathogenesis of oral lichen planus. This study aimed to assess Glutathione reductase, catalase, and free thiol levels in the saliva of OLP patients and compare it with healthy people. Methods: In this cross-sectional study, 35 patients with OLP and 20 healthy people were involved. Five mL of whole, unstimulated saliva samples were collected in the morning, and the salivary levels of antioxidants were measured by ELISA technique. In this experiment, sex, age and OLP types were also evaluated. Results: There was a significant decrease in the salivary level of Glutathione reductase and catalase in patients (p=0.001), but there were no differences between the two groups regarding free-thiol level (p=0.7). However, there was no correlation between age and gender with the antioxidants’ contents. There was a significant decrease in glutathione reductase and catalase in the erosive type than in the non-erosive type. Conclusions: In this study, we found that the salivary levels of Glutathione reductase and Catalase were lower in OLP patients than in the healthy group, which means these antioxidants were affected by OLP and also related to the type of it. So salivary Glutathione reductase and Catalase levels may be used as biomarkers for OLP monitoring and treatment.

Introduction: Temporomandibular joint disorders (TMD) are characterized by jaw pain combined with dysfunction of the muscles and joints. Extreme fabrication of oxidative stress in the TMJ thus results in tissue injury, which advances to TMD.The aim of this study was to evaluate the Glutathion reductase, catalase, and free thiol in saliva of TMD patients and compare it with people without TMD. Materials and Methods In this cross sectional study 35 patients with temporomandibular joint and 20 people without TMD were participated in the study. Five mL of each unstimulated saliva sample was collected in the morning and salivary level of antioxidants was assessed by ELISA (Enzyme Linked Immunosorbent Assay) technique. Helkimo index and visual analogue scale (VAS) also were measured during this experiment. Results There was significantly decrease in salivary level of Glutathion reductase and catalase in patients but there were no differences among two groups in free-thiol level.There was also correlation between antioxidant status and presence of click, pain and severity of disease; however, there was no correlation between age and gender with antioxidants contents. Conclusion The mean salivary levels of Glutathion reductase and Catalase in TMD patients were lower than that in the control group, which means these antioxidants were affected by TMD and also related with severity of it, but no significant difference was detected in salivary Free thiol between groups. So salivary Glutathion reductase and Catalase level may be used as a biomarker for TMD monitoring and treatment.