Objectives This study aimed to assess the relationship of skeletal class of malocclusion with some radiomorphometric indices of the mandible in short-face patients. Materials and Methods This cross-sectional study was conducted on 179 short-face patients between 17 to 30 years who sought orthodontic treatment during 2013 to 2020. The gonial and antegonial angles, and type and depth of antegonial notch were assessed bilaterally on traced panoramic radiographs. The correlation between radiomorphometric indices and class of malocclusion was analyzed by SPSS version 25 (alpha = 0.05). Results The mean size of gonial angle was significantly different among the three classes of malocclusion (P < 0.001), and the largest gonial angle was recorded in class III, and the smallest in class I patients. The mean size of antegonial angle and antegonial depth were not significantly different among the three classes of malocclusion (P > 0.05). The difference in the mean size of gonial and antegonial angles was not significant between males and females (P > 0.05). However, the mean antegonial depth in males was significantly greater than that in females (P < 0.001). Type I antegonial notch was more common in females than males at both sides. Age had no significant correlation with gonial angle, antegonial angle, or antegonial notch depth (P > 0.05). Conclusion Facial growth pattern in short-face patients can be predicted with antegonial angle.Also there is significant correlation of skeletal class of malocclusion with size of gonial angle. Clinical Relevance: The present results emphasized on the role of antegonial angle in prediction of facial growth pattern in short-face patients, and revealed significant correlation of skeletal class of malocclusion with size of gonial angle.