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While conventional explanations of drop-out and grade repetition acknowledge the role of socioeconomic factors, this paper uses data collected in a KwaZulu-Natal study of adolescents to investigate the explicit contribution of poverty and shocks to school disruption episodes. The asset-vulnerability framework developed by Moser and others is used to develop a poverty-based theory of school disruption. Evidence against such a theory is also put forward. The results indicate that the poverty-based theory accounts in part for school disruption. Poverty is predictive of school disruption, female adolescents are particularly vulnerable to drop-out episodes, and adolescent pregnancy emerges as an important influence. However, household shocks do not seem to predict school disruption. Programmes that offer incentives for school attendance and improving school quality are put forward as policy options for South Africa.drop-out, grade repetition, poverty, shocks,

Duchenne muscular dystrophy (DMD) is a serious, rare genetic disease, affecting primarily boys. It is caused by mutations in the DMD gene and is characterized by progressive muscle degeneration that results in loss of function and early death due to respiratory and/or cardiac failure. Although limited treatment options are available, some for only small subsets of the patient population, DMD remains a disease with large unmet medical needs. The adeno-associated virus (AAV) vector is the leading gene delivery system for addressing genetic neuromuscular diseases. Since the gene encoding the full-length dystrophin protein exceeds the packaging capacity of a single AAV vector, gene replacement therapy based on AAV-delivery of shortened, yet, functional microdystrophin genes has emerged as a promising treatment. This article seeks to explain the rationale for use of the accelerated approval pathway to advance AAV microdystrophin gene therapy for DMD. Specifically, we provide support for the use of microdystrophin expression as a surrogate endpoint that could be used in clinical trials to support accelerated approval.

South Africa's approach to care provision in the era of HIV/AIDS is home-and communitybased care, but in reality care for ill people in the home is provided on an unpaid basis, predominantly by women. But how much do they spend on this care work, in time and money? And what economic consequences does this policy have, particularly for poorer women? This article is based on findings from a study that focuses on unpaid care provision within the home for those in late-stage HIV/AIDS in KwaZulu-Natal, South Africa, and specifically on the costs of such provision. The findings show that female caregivers are bearing the bulk of the costs of care provision for ill people within the home on an unpaid basis. Home-based care is cost-effective for the provincial government but not for unpaid caregivers who are subsidizing the provincial economy. While hospital care for people with HIV/AIDS has been capped, home-based care services have not been increased to a commensurate level. Unpaid caregivers and ill people within the home are largely disconnected from the health system. The analysis clearly shows that the home-based care policy is not resulting in appropriate or sufficient support for these individuals in need and needs to be revised.

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