Background: The Surakarta Center for Community Lung Health is the UPT of the Indonesian Ministry of Health which in its service process produces wastewater. The results of the NH3 parameter check still show results above the threshold determined by Central Java Provincial Regulation No. 5 of 2012 which is 0.5 mg / lt while the standard is 0.1 mg / lt. TSS examination results are also still above the threshold determined by Central Java Perda No. 5 of 2012 which is 38-43 mg / lt while the standard is 30 mg / lt. Research Methods: This research is a pure experiment with a pretest-posttest group design. The population of this study is the wastewater wastewater WWKPM Surakarta. The sample of this study were 15 samples of liquid waste. The independent variable is EM-4 and the dependent variable is NH3 and TSS. Analysis of the data used is descriptive analysis). Results: The results showed that the Ammonia (NH3) level of BBKPM Surakarta wastewater prior to the EM-4 administration treatment was 1.03 mg / lt, the total Suspended Solid (TSS) liquid waste before the EM-4 administration treatment was 59 mg / lt , and Ammonia (NH3) levels of liquid waste after EM-4 treatment is <0.002 mg / lt either with the addition of 10 ml, 20 ml or 30 ml EM-4. Total levels of Suspended Solid (TSS) Surakarta BBKPM liquid waste after the treatment of EM-4 administration was 53 mg / lt with the addition of 10 ml EM-4, 52 mg / lt with the addition of 20 ml EM-4, 51 mg / lt with the addition EM-4 as much as 30 ml. Conclusion: The results showed that the administration of EM-4 was effective in reducing NH3 levels and was not yet effective in reducing TSS Surakarta BBKPM liquid waste. The most effective EM-4 dose for reducing NH3 and TSS levels in liquid waste is 10 ml.