Future precision measurements of the Standard Model (SM) parameters at the proposed Z-factories and Higgs factories may have significant impacts on new physics beyond the Standard Model in the electroweak sector. We illustrate this by focusing on the Type-II two Higgs doublet model (Type-II 2HDM). The contributions from the heavy Higgs bosons at the tree-level and at the one-loop level are included in a full model parameter space. We perform a multiple variable global fit and study the extent to which the parameters of nonalignment and non-degenerate masses can be probed by the precision measurements. We find that the allowed parameter ranges are tightly constrained by the future Higgs precision measurements, especially for small and large values of tan β. Indirect limits on the masses of heavy Higgs can be obtained, which can be complementary to the direct searches of the heavy Higgs bosons at hadron colliders. We also find that the expected accuracies at the Z-pole and at a Higgs factory are quite complementary in constraining mass splittings of heavy Higgs bosons. The typical results are | cos(β − α)| < 0.008, |∆m Φ | < 200 GeV, and tan β ∼ 0.2 − 5. The reaches from CEPC, FCC-ee and ILC are also compared, for both Higgs and Z-pole precision measurements.

We explore the extent to which future precision measurements of the Standard Model (SM) observables at the proposed Z-factories and Higgs factories may have impacts on new physics beyond the Standard Model, as illustrated by studying the Type-I Two-Higgs-doublet model (Type-I 2HDM). We include the contributions from the heavy Higgs bosons at the tree-level and at the one-loop level in a full model-parameter space. While only small tan β region is strongly constrained at tree level, the large tan β region gets constrained at loop level due to tan β enhanced tri-Higgs couplings. We perform a multiple variable χ 2 fit with non-alignment and non-degenerate masses. We find that the allowed parameter ranges could be tightly constrained by the future Higgs precision measurements, especially for small and large values of tan β. Indirect limits on the masses of heavy Higgs bosons can be obtained, which can be complementary to the direct searches of the heavy Higgs bosons at hadron colliders. We also find that the expected accuracies at the Zpole and at a Higgs factory are quite complementary in constraining mass splittings of heavy Higgs bosons. The typical results are | cos(β − α)| < 0.05, |∆m Φ | < 200 GeV, and tan β 0.3. The reaches from CEPC, Fcc-ee and ILC are also compared, for both Higgs and Z-pole precision measurements. Comparing to the Type-II 2HDM, the 95% C.L. allowed range of cos(β − α) is larger, especially for large values of tan β.

We explore the extent to which future precision measurements of the Standard Model (SM) observables at the proposed Z-factories and Higgs factories may have impacts on new physics beyond the Standard Model, as illustrated by studying the Type-I Two-Higgsdoublet model (Type-I 2HDM). We include the contributions from the heavy Higgs bosons at the tree-level and at the one-loop level in a full model-parameter space. While only small tan β region is strongly constrained at tree level, the large tan β region gets constrained at loop level due to tan β enhanced tri-Higgs couplings. We perform a multiple variable global fit with nonalignment and non-degenerate masses. We find that the allowed parameter ranges could be tightly constrained by the future Higgs precision measurements, especially for small and large values of tan β. Indirect limits on the masses of heavy Higgs bosons can be obtained, which can be complementary to the direct searches of the heavy Higgs bosons at hadron colliders. We also find that the expected accuracies at the Z-pole and at a Higgs factory are quite complementary in constraining mass splittings of heavy Higgs bosons. The typical results are | cos(β − α)| < 0.05, |∆m Φ | < 200 GeV, and tan β 0.3. The reaches from CEPC, FCCee and ILC are also compared, for both Higgs and Z-pole precision measurements. Comparing to the Type-II 2HDM, the 95% C.L. allowed range of cos(β − α) is larger, especially for large values of tan β.

The porcine sapovirus (SaV) (PoSaV) Cowden strain is one of only a few culturable enteric caliciviruses. Compared to the wildtype (WT) PoSaV Cowden strain, tissue culture-adapted (TC) PoSaV has two conserved amino acid substitutions in the RNAdependent RNA polymerase (RdRp) and six in the capsid protein (VP1). By using the reverse-genetics system, we identified that 4 amino acid substitutions in VP1 (residues 178, 289, 324, and 328), but not the substitutions in the RdRp region, were critical for the cell culture adaptation of the PoSaV Cowden strain. The other two substitutions in VP1 (residues 291 and 295) reduced virus replication in vitro. Three-dimensional (3D) structural analysis of VP1 showed that residue 178 was located near the dimer-dimer interface, which may affect VP1 assembly and oligomerization; residues 289, 291, 324, and 328 were located at protruding subdomain 2 (P2) of VP1, which may influence virus binding to cellular receptors; and residue 295 was located at the interface of two monomeric VP1 proteins, which may influence VP1 dimerization. Although reversion of the mutation at residue 291 or 295 from that of the TC strain to that of the WT reduced virus replication in vitro, it enhanced virus replication in vivo, and the revertants induced higher-level serum and mucosal antibody responses than those induced by the TC PoSaV Cowden strain. Our findings reveal the molecular basis for PoSaV adaptation to cell culture. These findings may provide new, critical information for the cell culture adaptation of other PoSaV strains and human SaVs or noroviruses. IMPORTANCEThe tissue culture-adapted porcine sapovirus Cowden strain is one of only a few culturable enteric caliciviruses. We discovered that 4 amino acid substitutions in VP1 (residues 178, 289, 324, and 328) were critical for its adaptation to LLC-PK cells. Two substitutions in VP1 (residues 291 and 295) reduced virus replication in vitro but enhanced virus replication and induced higherlevel serum and mucosal antibody responses in gnotobiotic pigs than those induced by the tissue culture-adapted strain. Structural modeling analysis of VP1 suggested that residue 178 may affect VP1 assembly and oligomerization; residues 289, 291, 324, and 328 may influence virus binding to cellular receptors; and residue 295 may influence VP1 dimerization. Our findings will provide new information for the cell culture adaptation of other sapoviruses and possibly noroviruses. C aliciviruses, in the family Caliciviridae, are small, icosahedral, and nonenveloped viruses with a diameter of 27 to 35 nm, which have a positive-sense, single-stranded RNA genome of 6.5 to 8.3 kb (1, 2). Caliciviruses have been classified into five genera (Norovirus, Sapovirus, Vesivirus, Lagovirus, and Nebovirus) and several proposed genera (3, 4). Among them, noroviruses (NoVs) and sapoviruses (SaVs) are the leading causes of gastroenteritis in humans of all ages. SaVs are often associated with sporadic, selflimiting gastroenteritis, the severity of which is reportedly milder t...

We study the domain wall solutions in the general two-Higgs-doublet model (2HDM) with a CP-violating phase. The 2HDM with the spontaneouse CP violation is found to have domain wall solutions whose tensions are $$ \mathcal{O} $$ O (106) GeV3, which are excluded by the Zel’dovich-Kobzarev-Okun bound. With the explicit CP-violating (CPV) terms as the so-called biased term in the scalar potential, domain walls can collapse in the early Universe. The sizes of the explicit CP violation can be constrained from the Big Bang nucleosynthesis. This constraint is converted to the CPV mixing of αc, and is mostly sensitive to the mass splittings between two heavy neutral Higgs bosons. We estimate the possible gravitational wave signals and the electric dipole moment (EDM) predictions due to the domain wall collapsing. It turns out that the peak spectrum of the GW from the domain wall collapsing cannot be probed in any future program. In contrast, the untenable regions with very tiny explicit CPV parameter in the Higgs potential has been partially excluded by the latest electron EDM measurements at the ACME-II and will be further confirmed or excluded by the future ACME-III projection.