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Abstract. With frequent air pollution episodes in China, growing research emphasis has been put on quantifying meteorological influences on PM 2.5 concentrations. However, these studies mainly focus on isolated cities, whilst meteorological influences on PM 2.5 concentrations at the national scale have not yet been examined comprehensively. This research employs the CCM (convergent cross-mapping) method to understand the influence of individual meteorological factors on local PM 2.5 concentrations in 188 monitoring cities across China. Results indicate that meteorological influences on PM 2.5 concentrations have notable seasonal and regional variations. For the heavily polluted North China region, when PM 2.5 concentrations are high, meteorological influences on PM 2.5 concentrations are strong. The dominant meteorological influence for PM 2.5 concentrations varies across locations and demonstrates regional similarities. For the most polluted winter, the dominant meteorological driver for local PM 2.5 concentrations is mainly the wind within the North China region, whilst precipitation is the dominant meteorological influence for most coastal regions. At the national scale, the influence of temperature, humidity and wind on PM 2.5 concentrations is much larger than that of other meteorological factors. Amongst eight factors, temperature exerts the strongest and most stable influence on national PM 2.5 concentrations in all seasons. Due to notable temporal and spatial differences in meteorological influences on local PM 2.5 concentrations, this research suggests pertinent environmental projects for air quality improvement should be designed accordingly for specific regions.

Highlights d FGF15 activates Mst1/2 through hepatic FGFR4 in response to increased bile acids d NF2 switches FGFR4's role from pro-oncogenic to anti-tumor signaling via Mst1/2 d Mst1/2 acts as a key negative feedback suppressor of bile acid synthesis via SHP d Depletion of bile acids retards Mst1/2-mutant-driven liver growth and oncogenesis