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Hepatocellular carcinoma (HCC) is associated with some of the highest cancer-associated mortality rates. Histone deacetylase (HDAC) inhibitors anti-HCC activities have been shown to promote Snail-induced metastasis. In the present study, it was shown that BAY 87-2243, a hypoxia-inducible transcription factor-1α inhibitor, could enhance the anti-HCC effects of HDAC inhibitors, including trichostatin A and vorinostat. In addition, BAY 87-2243 plus HDAC inhibitors exhibited synergistic cytotoxicity and induced significant cell death in Hep3B cells. Additionally, BAY 87-2243 combined with HDAC inhibitors-treated Hep3B cells formed fewer and smaller colonies as compared with either the control or single agent-treated cells. Furthermore, glycogen synthase kinase-3β might be involved in the enhanced cell death induced by BAY 87-2243 plus HDAC inhibitors. The present data also indicated that BAY 87-2243 combined with HDAC inhibitors could suppress the migration of Hep3B cells, and BAY 87-2243 could reverse the HDAC inhibitor-induced Snail activation in Hep3B cells. In conclusion, BAY 87-2243 combined with HDAC inhibitors might be an attractive chemotherapy strategy for HCC therapy.

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Abstract. Color image segmentation is a key technology in the field of computer vision. The quality of the segmentation results has a decisive influence on the quality of subsequent image analysis. In essence, computer vision is used a computer to replace the human vision to complete the target extraction and determination. Most of the traditional methods focus on ontology characteristics and ignore the role of human in the analysis process. In recent years, the visual saliency which simulates the process of the extraction of visual object by the human has been greatly improved in the field of image segmentation. Firstly, the visual attention calculation model is introduced. Then, the applications of visual attention calculation model in color image segmentation were summarized. Finally, the challenges in visual attention modeling at present were analyzed.