This research focused on the development of multimedia and interactive system, through network for learning in the opportunities school. This system was used as a channel for students to learn outside the classroom and as a teaching management tool for teachers. Tools for system development were Microsoft Visual Studio program while the database management system was MySQL. PHP and Java scripts were for writing commands. To evaluate the efficiency of the developed system, sample group and questionnaires were processed. The population of this research was a group of teachers and students of the Bankamwa school (Weboonratsamakee) in total of 97 people. The result of experiment shows that group recognizes the performance of system in the higher level and the system is efficient for its purposes.