BackgroundThe importance of prognostication in critical care cannot be over-emphasized, especially in the context of diseases like dengue, as their presentation may vary from mild fever to critical life-threatening illness. With the help of prognostic markers, it is possible to identify patients at higher risk and thus improve their outcome with timely intervention. Basic arterial blood gas (ABG) parameters, i.e., potential of hydrogen (pH), partial pressure of oxygen (PO2), partial pressure of carbon dioxide (PCO2) and bicarbonate are useful parameters, especially in critical care medicine as they are known to vary with the severity of illness. Hyperlactatemia is often referred to as a "powerful predictor of mortality". Basic ABG parameters and lactate have been used as an essential prognostic modality in critically ill patients for decades; however, the evidence remains limited for their role as prognostic markers in patients with severe dengue. Method

Ayurveda and contemporary science comprehends human body as model to understand disease state from very different perspective hence their methodology to describe disease manifestation also seems very different as they observe same problem from different viewpoints. For more precision in healthcare system it is essential that best of both systems need to be integrated, In Ayurvedic texts, the description of concept of basic constitution/Prakriti in health and disease states is well described. The scripts are not clearly understandable and hence its importance has not been properly understood by contemporary biological researchers and thus not utilized. According to Ayurveda individual's basic constitution (Prakriti) influences and directs one's disease status, its treatment & lifestyle regimen. In genomics, individual's basic constitution is decided by its genetic makeup. The current trend in Ayurveda-related biomolecular studies is establishment of high correlation between Prakriti and Genomics. This approach of Ayurgenomics would facilitate the development of alternative methods for cost effective screening of predisposed individuals in the population. This would result in development of an integrated approach to systems biology for disease and health state. For the establishment and success of this concept the prerequisite is integration of Ayurveda into mainstream contemporary biology to achieve global acceptability for the concepts and science of Ayurveda, and for this Ayurvedic concept based phenotypic (Prakriti) assessment needs to be made so that difference among individuals from large population based on their physical, physiological and psychological status can be observed and they can be categorized by their specific predominant Prakriti i.e. Vata, Pitta, Kapha. Information about individual predominant Prakriti can be further analyzed on certain genomic parameters related to gene expression, genetic, epigenetic and biochemical factors, which can be further utilized for Integration of Ayurveda with Genomics for systems biology approach in predictive and personalized medicine.

Background: The term "diabetes mellitus" describes a metabolic disorder of multiple aetiology characterized by chronic hyperglycemia. The GOI’s NPCDCS has a focus on awareness generation for behaviour and life-style changes, screening and early diagnosis of persons with high level of risk factors and their referral to appropriate treatment facilities. Earlier studies have reported that knowledge of patients about diabetes care leads to better glycemic control.Methods: A cross-sectional study conducted over a period of 3 months among diabetic patients coming to private OPD in Bareilly city. Patients with any other serious morbidity were excluded from the study.Results: Mean age was 61.8±13.4 years. Mostly subjects did not know the type of diabetes they had (42, 75.0%) amongst those who knew, majority had type-2 diabetes (9, 16.1%).  Majority had no known history of diabetes in the family (31, 55.4%). Most of the study subjects had diabetes diagnosed for five years or less (26, 46.4%). Most common co-morbidity was hypertension (33, 58.9%) followed by obesity (29, 51.8%). Majority of subjects (23, 41.1%) followed some dietary advice and a little less than half performed exercise daily. Approximately two-third of the subjects (38, 67.9%) did not have blood sugar testing in the previous week and most subjects (31, 55.4%) did not care for their feet. Majority (39, 69.6%) took regular medicine.Conclusions: It is evident that better education is related to good self-care. Masses need to be made aware regarding self-care emphasizing on foot care and regular blood sugar testing.

Background: Pulmonary Tuberculosis (PTB) is a contagious, airborne infection that develops when M. tuberculosis infect the lungs. PTB is totally curable infection. However, an early diagnosis and antibiotic treatment is needed to get the desired outcomes. Despite availability of treatment, stigmatization and negative emotions resulting from the illness could hamper the psychological well-being of patients which may eventually result in poor compliance, work absenteeism thus effecting economic productivity and prosperity. Methods: This was a cross-sectional study conducted over a period of one year. A total of 231 category II DOTS patients were recruited for the study. Quality of Life (QOL) was assessed after 3 months of the intensive phase. For QOL WHO based QOLBREF was used. Results: In the present study patients scored lowest in the psychological domain (7.82 ± 1.86) followed by physical (8.21 ± 1.98). Conclusion: HRQOL is significantly reduced in patients with PTB.