Although pneumocystis jiroveci pneumonia was historically associated with HIV/AID patients, there is a recent shift in demographics with increasing incidence in patients with hematologic malignancies and transplants. A granulomatous response to pneumocytis jiroveci infection is uncommon and most commonly presents as multiple randomly distributed nodules on chest imaging. Granulomatous pneumocytis jiroveci pneumonia presents with similar clinical manifestations as typical pneumocytis pneumonia but is usually not detected by bronchoalveolar lavage and may require biopsy for a definitive diagnosis. For this reason, the radiologist may be the first provider to suggest this diagnosis and guide management.

This book was inadvertently published with sensitive patient information in Figure 3.9 of this chapter for which we did not have permission to display. We have now revised the figure wherein the date of birth of this patient has been whited out.

Dr. Purushottam Vishwanath Gharpure was an eminent Indian pathologist and an emeritus Professor of Pathology at the Grant Medical College, Bombay. He was a pioneer in carrying out the first field trial of polio vaccination which marked the beginning of the polio eradication program in India. Dr. Gharpure set an example by taking his laboratory work to the field and proving how the laboratory research can be used to better the society. The mesmerizing story of Dr. “Gharpure's life” is described in this paper.

Introduction/Objective Gastrointestinal stromal tumors (GIST), albeit very rare overall, with approximately 5,000 new diagnoses yearly in the US, represent the most common mesenchymal tumor involving the GI tract. particularly the stomach and small bowel. Pogress has been made in the past two decades in terms of describing pathogenesis, classification, and targeted therapy of GIST, however, their behavior is still quite challenging and unpredictable, and their prognosis remains guarded. Methods/Case Report We reviewed our institutional experience with GIST between 2010-2020; the review included surgical pathology reports, charts, and slides and we extracted data relevant for better characterization of these rare tumors. Results (if a Case Study enter NA) We identified a total of 53 GIST, with a preponderance of females (37 cases) versus males (16), and age ranging from 33yo (female) to 90yo (female). The majority of tumors were located in the stomach (39), with the remaining distributed between different locations: colon, small bowel, duodenum (3 each), esophagus and liver (2 each) and retroperitoneum (1). The GISTs ranged in size from 0.2 to 30 cm. 14 GISTs were smaller than 1 cm, with 8 of these being incidental findings: 4 associated with another tumor, 3 in sleeve gastrectomies, and 1 in a colon resected for perforated diverticulitis. Six GISTS were multiple, with 2-3 different tumors in the stomach, corresponding to a pT1m or pT2m stage. Majority of GISTs were spindled, while only 3 GISTwere mixed and 2 were epithelioid. All GIST in our review were c-kit positive. Conclusion In summary, we report data obtained from 53 resected GIST’s over a 10 year period. GIST ia a rare tumor overall, with an annual incidence of 10-20 new cases/ million, and therefore it is relatively difficult to study. Our findings confirm those reported in the literature as far as localization (preponderence of stomach), gender prevalence (female) and predominant proto-oncogen kit mutation, but shows a wider age range and interesting co-morbid associations in small, no risk GIST. These findings support the hypothesis that tumor microenvironment and host immune response are important factors in pathogenesis and provides empirical evidence that immunotherapy and immunomodulation should be studied as therapeutic additions in GIST.