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Key Points Question Are opioid use disorder (OUD) medications associated with alcohol-related poisonings, falls, and injuries in persons with OUD and co-occurring alcohol use? Findings This case-control cohort study of 13 335 individuals with OUD from a large, nationally representative data set found that patients prescribed OUD medication had significant reductions in alcohol-related acute events. Meaning The use of OUD medication in opioid-dependent patients with co-occurring alcohol use may hold promise in reducing alcohol-related acute events, but more investigation is needed.

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(75% IMPT, 78% IMRT). There was no significant difference in number of pts who underwent surgery (47% IMPT, 56% IMRT) and of those, no difference in pathologic complete response rates (33% IMPT, 39% IMRT). Post-operative complications were also similar between groups including pneumonia, anastomotic leak, anastomotic stricture, and cardiac arrhythmia rates. At one year, clinical outcomes were (for IMPT vs IMRT, respectively): local control 92 vs 84%, local-regional control 92 vs 80%, distant metastasis-free survival 87 vs 65%, and overall survival 74 vs 71% (none statistically significant between groups). IMPT pts had statistically significantly improved progression free survival (PFS) (75% vs 47%, PZ0.02), and it remained significant for improved PFS in the final MVA model (PZ0.04). No statistically significant association was seen between the two groups for acute treatment-related grade 3 toxicities (PZ0.47). Conclusion: We report early, promising retrospective evidence for safety and efficacy of IMPT compared to IMRT for EC. Direct comparative studies of IMPT vs. IMRT utilizing prospective trials accruing larger, balanced patient cohorts are warranted in the future.