We argue for network slicing as an efficient solution that addresses the diverse requirements of 5G mobile networks, thus providing the necessary flexibility and scalability associated with future network implementations. We elaborate on the challenges that emerge when we design 5G networks based on network slicing. We focus on the architectural aspects associated with the coexistence of dedicated as well as shared slices in the network. In particular, we analyze the realization options of a flexible radio access network with focus on network slicing and their impact on the design of 5G mobile networks. In addition to the technical study, this paper provides an investigation of the revenue potential of network slicing, where the applications that originate from such concept and the profit capabilities from the network operator's perspective are put forward.

'Where's' in a name?

BackgroundSelf-management support can improve health and reduce health care utilization by people with long-term conditions. Online communities for people with long-term conditions have the potential to influence health, usage of health care resources, and facilitate illness self-management. Only recently, however, has evidence been reported on how such communities function and evolve, and how they support self-management of long-term conditions in practice.ObjectiveThe aim of this study is to gain a better understanding of the mechanisms underlying online self-management support systems by analyzing the structure and dynamics of the networks connecting users who write posts over time.MethodsWe conducted a longitudinal network analysis of anonymized data from 2 patients’ online communities from the United Kingdom: the Asthma UK and the British Lung Foundation (BLF) communities in 2006-2016 and 2012-2016, respectively.ResultsThe number of users and activity grew steadily over time, reaching 3345 users and 32,780 posts in the Asthma UK community, and 19,837 users and 875,151 posts in the BLF community. People who wrote posts in the Asthma UK forum tended to write at an interval of 1-20 days and six months, while those in the BLF community wrote at an interval of two days. In both communities, most pairs of users could reach one another either directly or indirectly through other users. Those who wrote a disproportionally large number of posts (the superusers) represented 1% of the overall population of both Asthma UK and BLF communities and accounted for 32% and 49% of the posts, respectively. Sensitivity analysis showed that the removal of superusers would cause the communities to collapse. Thus, interactions were held together by very few superusers, who posted frequently and regularly, 65% of them at least every 1.7 days in the BLF community and 70% every 3.1 days in the Asthma UK community. Their posting activity indirectly facilitated tie formation between other users. Superusers were a constantly available resource, with a mean of 80 and 20 superusers active at any one time in the BLF and Asthma UK communities, respectively. Over time, the more active users became, the more likely they were to reply to other users’ posts rather than to write new ones, shifting from a help-seeking to a help-giving role. This might suggest that superusers were more likely to provide than to seek advice.ConclusionsIn this study, we uncover key structural properties related to the way users interact and sustain online health communities. Superusers’ engagement plays a fundamental sustaining role and deserves research attention. Further studies are needed to explore network determinants of the effectiveness of online engagement concerning health-related outcomes. In resource-constrained health care systems, scaling up online communities may offer a potentially accessible, wide-reaching and cost-effective intervention facilitating greater levels of self-management.

The plane of cell division is defined by the final position of the mitotic spindle. The spindle is pulled and rotated to the correct position by cortical dynein. However, it is unclear how the spindle's rotational center is maintained and what the consequences of an equatorially off centered spindle are in human cells. We analyzed spindle movements in 100s of cells exposed to protein depletions or drug treatments and uncovered a novel role for MARK2 in maintaining the spindle at the cell's geometric center. Following MARK2 depletion, spindles glide along the cell cortex, leading to a failure in identifying the correct division plane. Surprisingly, spindle off centering in MARK2-depleted cells is not caused by excessive pull by dynein. We show that MARK2 modulates mitotic microtubule growth and length and that codepleting mitotic centromere-associated protein (MCAK), a microtubule destabilizer, rescues spindle off centering in MARK2-depleted cells. Thus, we provide the first insight into a spindle-centering mechanism needed for proper spindle rotation and, in turn, the correct division plane in human cells.

Caching of video files on user devices, combined with file exchange through device-to-device (D2D) communications is a promising method for increasing the throughput of wireless networks. Previous theoretical investigations showed that throughput can be increased by orders of magnitude, but assumed a Zipf distribution for modeling the popularity distribution, which was based on observations in wired networks. Thus the question whether cache-aided D2D video distribution can provide in practice the benefits promised by existing theoretical literature remains open. To answer this question, we provide new results specifically for popularity distributions of video requests of mobile users. Based on an extensive real-world dataset, we adopt a generalized distribution, known as Mandelbrot-Zipf (MZipf) distribution. We first show that this popularity distribution can fit the practical data well. Using this distribution, we analyze the throughput-outage tradeoff of the cache-aided D2D network and show that the scaling law is identical to the case of Zipf popularity distribution when the MZipf distribution is sufficiently skewed, implying that the benefits previously promised in the literature could indeed be realized in practice. To support the theory, practical evaluations using numerical experiments are provided, and show that the cache-aided D2D can outperform the conventional unicasting from base stations.