BackgroundThe initial management of Acute bacterial skin and skin structure infection (ABSSSI) is burdensome. It requires empirical antibiotic therapy that covers both gram-positive and gram-negative bacteria. Vancomycin plus aztreonam are the most commonly used antibiotic combination, nonetheless, they have many limitations which limits their use. Hence, many new single agents with MRSA and gram-negative coverage, oral options, and/or good safety profile have been developed to be a potential alternative such as: ceftaroline, ceftobiprole, tigecycline and the recent FDA approved antibiotic (delafloxacin). In the absence of head-to-head trials comparing these agents, we decided to conduct a network meta-analysis for these therapeutic regimens.MethodsA Bayesian network meta-analysis of randomized clinical trials identified in PubMed/Medline and Embase databases was conducted. We performed both fixed and random effect models for clinical cure as the primary outcome of interest. Additionally, rankograms were generated using the surface under the cumulative ranking curve (SUCRA) to obtain the treatment ranking probabilities in relation to their relative effect.ResultsWe identified 10 eligible studies involving 4,914 patients. The indirect comparison demonstrated that delafloxacin showed no difference in terms of clinical cure compared with ceftaroline (OR, 0.82, 95% Cr.I 0.39–1.8), ceftobiprole (OR, 0.79, 95% Cr.I 0.32–1.9), SOC (OR, 1.2, 95% Cr.I 0.62–2.4) and tigecycline (OR, 1.0, 95% Cr.I 0.45–2.2) in the fixed effect analysis, nor in the random-effect analysis (OR, 0.8, 95% Cr.I 0.26–2.2; OR, 0.78, 95% Cr.I 0.2–3.0; OR, 1.2, 95% Cr.I 0.51–3.1; and OR, 0.96, 95% Cr.I 0.30–3.0), respectively. Furthermore, the ranking probabilities in the fixed-effect and random-effect analysis showed that ceftaroline was ranked the first in terms of clinical cure (SUCRA, 40.02%) followed by ceftobiprole (SUCRA, 22.80%), delafloxacin (SUCRA, 16.60%), SOC (SUCRA, 13.80%), and then tigecycline (SUCRA, 6.70%).ConclusionCeftaroline, ceftbiprole, delafoxacin, SOC and tigecycline are similarly effective. However, delafloxacin provides better convenience. Further comparative studies regarding their safety are needed. Disclosures All authors: No reported disclosures.

Introduction: During Hajj and Umrah season, asthma-related acute admissions produce the enormous burden on healthcare facilities and causes delay in admissions for more severe cases, e.g. myocardial infarction, cardiac failure and severe trauma cases. Therefore, the snapshot of asthma-related admissions during the Hajj and Umrah season was determined by asthma-related admissions and medication use and economic burden during Hajj and Umrah pilgrimage season. Methodology: All asthma-related admissions during the month of Ramadan (fasting month) and Hajj pilgrimage were assessed from patients’ data retrospectively. The convenience sampling strategy was used to retrieve study variables. Statistical Package for Social Science (SPSS) Version 22.0 was used to analyze the data. Results: A total of 271 patients were selected as per inclusion criteria, the majority of them were males 153 (56.5%), while most of them were Saudi 70 (35.8%) and Egyptians 86 (31.7%). During hospitalization, the common treatment for acute exacerbations was inhaled corticosteroids 224 (86.3%), IV corticosteroids 129 (47.6%), Inhaled short-acting beta-agonists 244 (90%) and inhaled bronchodilators (ipratropium bromide) 237(87.5 5%). Conclusion: This periodic mapping of asthma-related admissions and its management during these massive gathering events is indeed a significant effort to explore issues of acute asthma exacerbations management and to provide information to plan for future interventions and policies.

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Background:Medication delivery via enteral feeding tube require a specific precaution. As many medications are incompatible to be administered via feeding tube. Some medications are not acceptable to be crushed owing to the risk of obstruct the feeding tube, diminish drug efficacy or drug toxicity. While others will interact with the feeding formula and limit its absorption. this study aims to evaluate the prevalence of medication errors that occur during the administration of oral drugs using enteral feeding tubes in geriatric population in home health care.MethodologyThis is a cross sectional observational study conducted in ministry of health governmental hospital in Makkah city, Saudi Arabia. Oral drug administration was examined in 46 individuals in 2020. Demographic information, medical records and pharmaceutical prescription information regarding each patient was evaluated. The errors including improper dosage form and drug-nutrient interaction were measured per various guidelines.Result:A significant proportion of investigated populations had inappropriate drug administration. The majority of patients (86.9 percent) got improper dosage form by enteral feeding tube mainly gastrointestinal medicines. While drug-nutrient interaction was prominent in 36.9 percent of the patients with highly prevalent among neurological medicines. All patients’ caregiver obtained guidance by doctors and nurses solely. Gender, age, hospital, Type of ET, and educator were not associated with significant differences in appropriateness of dosage form or administration time.Conclusion:health care practitioners should display greater attention when choosing drugs dosage type for tube-fed patients and medication administration timing.