Diabetes mellitus is a serious debilitating longtime illness that grows in nearly 5% of the world’s peoples. People with this illness have a shortage of insulin or lessen capacity to use insulin; the hormone controlled blood glucose level. The study aims to assess the Karaya powder application among diabetic mellitus clients. The study was conducted in Mappedu village with 60 samples. The data was collected by using Structure interview questionnaires on Karaya powder. The result revealed that extract has significant effect increase knowledge on Karaya powder application on diabetic wound healing among diabetic clients.