Chronic mix-pesticide exposure among workers involved in mosquito control has possible association with depression of diazoxonase and the increase in ox-LDL, brachial and aortic DBP and SBP, and heart rate. This study raises concerns that those using pesticides may be exposed to hitherto unrecognized CVS risks among others. If this is confirmed by further studies, greater efforts will be needed to protect these workers.

Air Handling Units in mechanical ventilation system possess a high degree of potential to circulate contaminants within occupied spaces of a building which often results in sick building syndrome (SBS), building related illness (BRI) and other indoor air quality (IAQ) related issues. This happens despite the expected role of ventilation systems to create a balance of thermal comfort and indoor air quality to the building occupants as well as the stored components. In the hot and humid climate mechanical ventilation systems play an important role of controlling the indoor hygrothermal conditions. Inadequate performance of the mechanical ventilation systems result in several issues ranging from human occupants discomfort, mechanical damages to archival materials and mould problem amongst others. This study presents the measurement and analysis of the mechanical ventilation systems' performance and its effect on various indoor spaces in an academic building in Malaysia. Measurement of airflow, thermal and hygric conditions of the facility together with the aero-biological sampling were executed. The ventilation performance assessment revealed that the AHU fails in its cooling and dehumidification capacities as most of the occupied zones witnessed elevated humidity and low temperature and hence poor hygrothermal performance. On the other hand, results of bio-aerosol assessment indicates that the AHU performs well in its decontamination capacities by reducing the microbial level between the AHU and the occupied zones. The dominant species of mould in the assessed spaces are Penicillium sp., Yeast, Cladosporium sp., and Chaetomium sp. with 100 % occurrence in all the assessed space. On the other hand, Black Mold, Syntalidium sp., and zygomycetes are the least species in spaces with 25 % occurrence. The presence of black mould portends a great danger to the occupants' health and therefore requires urgent attention.

Occupational diseases are one of the major health problems related to workplace hazards. However, the epidemiological data for this problem is scarce especially among Small and Medium Industry (SMI) workers. These workers are vulnerable to occupational health problem due to lack of knowledge and implementation of health and safety in the workplace. In Malaysia, most of the SMI workers have limited coverage for basic occupational health services which may worsen their health. Thus, this article aims to provide a review on the burden of occupational health problems among them. The electronic and library searches were used to extract the information from both published and unpublished articles that were not limited to any year of publication until 2017. One hundred and ninety-six published articles and 198 unpublished articles were retrieved from the database. Only 19 published articles and 25 unpublished articles met the eligibility criteria. Prevalence data of occupational diseases/poisoning, including overall and body specific (musculoskeletal disorders) was extracted in raw data from the eligible studies. Prevalent statistics on occupational musculoskeletal diseases (1.3% - 97.6%), noise-induced hearing loss (29.4% - 73.3%), occupational skin diseases (10.5% - 84.3%), respiratory (1.9% - 92.2%) and occupational poisoning (14.9% - 17.7%) among the working population is different within published papers compared to unpublished ones. In Malaysia, there are no specific statistic that give a true picture of the burden of occupational diseases in the SMI. However, this review concludes that musculoskeletal diseases are significant occupational problems among SMI workers.

Approximately 100 million people are exposed to arsenic worldwide, majorly through drinking water and anthropogenic activities. Monosodium methylarsonate (MSMA) is a potent organoarsenical content of herbicides used in many Asian countries. Epidemiological studies have linked inorganic arsenic exposure with atherosclerosis, whereas organoarsenicals toxicological studies are scanty. Paraoxonase 1 (PON1) enzyme suppresses systemic Ox-LDL generation, thereby preventing atherosclerosis. We investigated effects of MSMA oral exposure on PON1, lipid peroxidation and atherosclerosis development. Five groups (n=11) of Sprague -Dawley rats received daily intubation of MSMA at 0 (control), 42.1, 63.2, 126.4 and 210.7 mg/kg BW respectively for 16 weeks. Serum samples were analysed for PON1 activities, Ox-LDL and MDA levels. Histomorphometric evaluation (H&E and VVG) and immunohistochemistry (VCAM-1 and ICAM-1) were done on aorta. High mortality rate led to discontinuation of 126.4 and 210.7 mg/kg BW treatment groups. Groups treated with 42.1 and 63.2 mg/kg B.W. MSMA had a significantly higher MDA (p=0.004,CI: 2.73-0.82) and Ox-LDL (p<0.0001,CI: 2425.07-955.45) levels but lower PON1:Ox-LDLratio (p<0.0001,CI: 0.49-1.07) compared to control. Microscopically, treatment groups showed early atherosclerotic intima thickening and positive VCAM-1 and ICAM-1 expressions. In conclusion, chronic MSMA exposure reduced PON1 ability to hydrolyse Ox-LDL and also induced inflammation by elevating oxidative stress that supports early atherosclerosis development.

Indoor mould contamination portends grave consequence to the stored components as well as inhabitants of infested dwellings. Such defilement, which is due to favourable growth environment for micro-organisms, is often associated with Sick Building Syndrome (SBS) and other Building Related Illness (BRI). As the economic development of Malaysia continues, increase numbers of air-tight, fully air conditioned buildings are evolving. Currently limited guidelines exists on Indoor Air Quality (IAQ) in Malaysia and its knowledge amongst the public is lacking. Hence, diagnosing the aggravating factors favouring indoor mould becomes beneficial as earlier detection is often difficult until growth has advanced. The study aimed at investigating mould infestation in a mechanically ventilated library building in Malaysia. Microclimate parameter and mould sampling were carried out. The microbial investigation results in 72 isolates whose distribution were 86 % mould, 13 % yeast and 1 % bacterial. It is found that Aspegillus sp. and Onychocola sp. were most common. The library internal microclimate distribution is characterised by uneven hygrothermal profile which results in high level of cellulolytic mould species that are highly detrimental to books and other archival materials. It is recommended that the HVAC system operations and set-points be critiqued to bring the ambient to the preservation requirements. In addition, load balancing for thermal and hygric distribution analysis should be executed to eliminate dead-spots in temperature and moisture distributions.