Introduction: The medical professional is under ever-increasing pressure, therefore he is subjected to ever-increasing stress, which may lead him to burnout. Our objective was to assess the burnout syndrome in physicians and interns in the two university hospital in Toliara and the associated factors. Materials and methods: This is a cross-sectional descriptive study, carried out among doctors and interns practicing in the two university hospital in Toliara using an anonymous questionnaire associated with the Maslach Burnout Inventory scale. Results: We recruited 47 practitioners. The average age of our study population was 39.51 years, 57.4% were men and 42.6% were women with a sex ratio of 1.35. Among Burnout practitioners, 32% were emotionally exhausted, 17% depersonalized, 45% had a low personal accomplishment score. Fifty-nine decimal six percent (59.6%) were in burnout, 8.6% had a high burnout score. Several factors were associated with burnout: female gender (p=0.001), young age (p=0.03), sleep quality (p=0.002), lack of theoretical and practical knowledge (p=0.02) and insufficient technical trays (p=0.03). Conclusion: Burnout syndrome is a reality. The implementation of concrete measures would seem essential, such as improving working conditions to reduce the development of this scourge.