An experiment was conducted at BINA (Bangladesh Institute of Nuclear Agriculture) substation, Satkhira on slightly calcareous silty clay soil during the boro season of 2009-2010 to investigate the effects of different combinations of inorganic fertilizers in order to achieve sustainable high yield goal in the STL-655 rice mutant cultivar. The six treatment combinations were: T 1 (absolute control), T 2 (N 60 P 20 K 40 S 10 Zn 1 ), T 3 (N 80 P 25 K 50 S 15 Zn 1.5 ), T 4 (N 100 P 30 K 60 S 20 Zn 2 ), T 5 (N 120 P 35 K 70 S 25 Zn 3 ) and T 6 (N 140 P 40 K 80 S 30 Zn 4 ) that was laid out in a randomized complete block design (RCBD) with three replications having per plot size was 5m x 4m. The results revealed that grain and straw yields of STL-655 rice mutant responded significantly with the different treatment combinations. The highest grain (3.95 t/ha) and straw yield (7.38 t/ha) was obtained in T 6 (Soil test basis high yield goal) treatment, which was significantly higher than all other treatments. The treatment T 6 (N 140 P 40 K 80 S 30 Zn 4 ) caused an increase of 60% grain yield and 27% higher straw yield over the control. Nutrient uptake of N, P, K and S by grain of boro rice (STL-655 rice mutant) varied from 25.14 to 48.02, 5.40 to 8.14, 11.76 to 23.02 and 4.15 to 7.09 kg/ha, respectively. The N, P, K and S uptake by straw of boro rice (STL-655 rice mutant) varied from 20.36 to 35.85, 5.47 to 11.05, 59.01 to 159.6 and 9.54 to 12.97 kg/ha, respectively.