Dermal injuries (e. g., trauma, surgical incisions, and burns) are burdensome health care issues in the world. The delayed healing process can be caused by aerobic and anaerobic bacteria infections, including Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus and Enterococcus species, Pseudomonas aeruginosa, Peptostreptococcus, and Coliforms. Therefore, reduction of bacterial burden to an acceptable level promotes healing. The rationale for this innovative wound dressing relies on good hydration as the single most important external factor responsible for optimal wound healing. Objective: To study the wound healing potential of GEN nanogel films based on natural polymers using carrageenan (CAR) and Prosopis africana (PRO), a local African plant. Method: Nanogel dispersions and films were characterized by their physical and technological properties, microenvironment, Zeta sizer, Differential Scanning Calorimetry, FTIR spectroscopy, in vitro drug release, and efficacy of wound healing in the rat in a full-thickness excisional model. Results: GEN was dispersed in the polymers, with PROGEN films appearing smoother than CARGEN. Wound closure rate was 88, 76, and 72 % with PROGEN, CARGEN, and GENTA cream, respectively, whereas drug release was sustained in the order of PROGEN (~99 % at 8 h), CARGEN (83 % at 10 h), and pure GENTA powder (81% at 1 h). Topical administration of GEN nanogel-films significantly accelerated (< 15 days) wound closure with no scabbing observed compared to the commercial GENTA cream used. Conclusion: GEN-loaded PROGEN and/or CARGEN films have the potential for developing an improved and affordable topical treatment for cutaneous wound healing.