In this study, ondansetron was not found to be beneficial in the treatment of seasickness. It could be speculated that the mechanism of nausea in seasickness is different from that of toxin-induced nausea.

Background: Sedation in terminally-ill cancer patients is typically used to alleviate symptoms of physical distress during the last week of life, in order to allow patients to achieve serenity. These include pain, as well as respiratory, neuropsychiatric, and gastrointestinal symptoms.