Current popular SOFC anode is made by composite cermet of Ni and yttria stabilized zirconia (YSZ). The interaction between Ni and YSZ at triple phase boundary (TPB) must be studied intensively to investigate anode degradation mechanism. In this study, the degradation phenomena at the interface between Ni and YSZ have been investigated by using screen-printed pure Ni anode sintered on YSZ pellet. The time depended microstructural evolution of Ni-YSZ interface in long time galvanostatic polarization is studied in hydrogen with different humidities. Compared with normal composite cermet anode experiments, this method provides easy observation of the Ni-YSZ interface where degradation takes place. The microstructural changes were characterized by scanning electron microscopy (SEM). The influence of humidity on sintered pure Ni anode is investigated and the degradation mechanism at Ni-YSZ interface is discussed.