This paper documents the production and validation of retrieved rainfall data obtained from satellite-borne microwave radiometers by the Global Satellite Mapping of Precipitation (GSMaP) Project. Using various attributes of precipitation derived from Tropical Rainfall Measuring Mission (TRMM) satellite data, the GSMaP has implemented hydrometeor profiles derived from Precipitation Radar (PR), statistical rain/no-rain classification, and scattering algorithms using polarization-corrected temperatures (PCTs) at 85.5 and 37 GHz. Combined scattering-based surface rainfalls are computed depending on rainfall intensities. PCT85 is not used for stronger rainfalls, because strong depressions of PCT85 are related to tall precipitation-top heights. Therefore, for stronger rainfalls, PCT37 is used, with PCT85 used for weaker rainfalls. With the suspiciously strong rainfalls retrieved from PCT85 deleted, the combined rainfalls correspond well to the PR rain rates over land. The GSMaP algorithm for the TRMM Microwave Imager (TMI) is validated using the TRMM PR, ground radar [Kwajalein (KWAJ) radar and COBRA], and Radar Automated Meteorological Data Acquisition System (AMeDAS) precipitation analysis (RA). Monthly surface rainfalls retrieved from six microwave radiometers (GSMaP_MWR) are compared with the gauge-based dataset. Rain rates retrieved from the TMI (GSMaP_TMI) are in better agreement with the PR estimates over land everywhere except over tropical Africa in the boreal summer. Validation results of the KWAJ radar and COBRA show a good linear relationship for instantaneous rainfall rates, while validation around Japan using the RA shows a good relationship in the warm season. Poor results, connected to weakprecipitation cases, are found in the cold season around Japan.

Circadian rhythms provide organisms with an adaptive advantage, allowing them to regulate physiological and developmental events so that they occur at the most appropriate time of day. In plants, as in other eukaryotes, multiple transcriptional feedback loops are central to clock function. In one such feedback loop, the Myb-like transcription factors CCA1 and LHY directly repress expression of the pseudoresponse regulator TOC1 by binding to an evening element (EE) in the TOC1 promoter. Another key regulatory circuit involves CCA1 and LHY and the TOC1 homologs PRR5, PRR7, and PRR9. Purification of EE–binding proteins from plant extracts followed by mass spectrometry led to the identification of RVE8, a homolog of CCA1 and LHY. Similar to these well-known clock genes, expression of RVE8 is circadian-regulated with a dawn phase of expression, and RVE8 binds specifically to the EE. However, whereas cca1 and lhy mutants have short period phenotypes and overexpression of either gene causes arrhythmia, rve8 mutants have long-period and RVE8-OX plants have short-period phenotypes. Light input to the clock is normal in rve8, but temperature compensation (a hallmark of circadian rhythms) is perturbed. RVE8 binds to the promoters of both TOC1 and PRR5 in the subjective afternoon, but surprisingly only PRR5 expression is perturbed by overexpression of RVE8. Together, our data indicate that RVE8 promotes expression of a subset of EE–containing clock genes towards the end of the subjective day and forms a negative feedback loop with PRR5. Thus RVE8 and its homologs CCA1 and LHY function close to the circadian oscillator but act via distinct molecular mechanisms.

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We report three patients with selective topographic disorientation due to small, focal hemorrhages extending from the right retrosplenial region to the medial parietal lobe. All three could discriminate and identify familiar buildings and landscapes, but had great difficulty remembering spatial positional relationships between two distant locations (i.e., the direction from one location to another) in familiar areas. These symptoms were different than the perception and memory deficits for buildings and landscapes caused by the medial temporo-occipital lesion. These findings suggest that the directional orientation between two locations within a familiar area ("sense of direction") is closely associated with the right retrosplenial region and the medial parietal lobe in humans.

Short- and long-distance circadian communication is essential for integration of temporal information. However, a major challenge in plant biology is to decipher how individual clocks are interconnected to sustain rhythms in the whole plant. Here we show that the shoot apex is composed of an ensemble of coupled clocks that influence rhythms in roots. Live-imaging of single cells, desynchronization of dispersed protoplasts, and mathematical analysis using barycentric coordinates for high-dimensional space show a gradation in the strength of circadian communication in different tissues, with shoot apex clocks displaying the highest coupling. The increased synchrony confers robustness of morning and evening oscillations and particular capabilities for phase readjustments. Rhythms in roots are altered by shoot apex ablation and micrografting, suggesting that signals from the shoot apex are able to synchronize distal organs. Similarly to the mammalian suprachiasmatic nucleus, shoot apexes play a dominant role within the plant hierarchical circadian structure.