A new antibiotic, DB-2073, was isolated in crystalline form from the fermented broth of Pseudomonas sp. B-9004. The compound is a alkylresorcinol antibiotic. The antibiotic melts at 8688°C. The molecular weight of 236 was determined by mass spectroscopy and the molecular formula was calculated as C15H24O2. The antibiotic has antimicrobial activity against Gram-positive bacteria, mycobacteria and fungi.
A new antibiotic, samarosporin, was isolated in a crystalline state from a mycelial extract of a strain of Samarospora species (an ascomycete). Samarosporin is a neutral cyclopeptide and has a molecular formula of C12H111N15O19. Samarosporin shows a broad antimicrobial activity against various test microorganisms. A fungal strain No. F-7762 isolated from a soil sample was found to belong to the genus Samarospora of Ascomycetes. A cyclopeptide antibiotic was produced in the mycelium of the strain, and the compound was named samarosporin. The samarosporin-producing strain has been deposited in the Fermentation Research Institute, Chiba, Japan, with accession number FERM-P 224. The taxonomic study of the producing strain of the fungus will be reported in a separate paper.
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