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Dunning, under whose direction this work has been carried out* He is also indebted to Drs* Du M e 2 , Vanden Bosche, Broughton, Drake, Haring and White for their valuable instruction* Special thanks are due Professor M* R* Thompson for his assistance in the pharma cological studies of the compounds, and Dr* David I. Macht and Mr. Irvin LaBuff, of Hynson, Westcott and Dunning, Inc., for their assistance in the toxicological and bacteriological examination of the compounds* The author desires to acknowledge his thanks to Dr. H. A. B. Dunning for the generous grant of funds which has made this work possible, and for the unlimited use of the laboratories of Hynson, Westcott and Dunning, Inc.

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