No abstract

ACTIV-3/TICO Study Group* Background: Ensovibep (MP0420) is a designed ankyrin repeat protein, a novel class of engineered proteins, under investigation as a treatment of SARS-CoV-2 infection.Objective: To investigate if ensovibep, in addition to remdesivir and other standard care, improves clinical outcomes among patients hospitalized with COVID-19 compared with standard care alone.

Background: As opioid-related hospitalizations rise, hospitals must be prepared to evaluate and treat patients with opioid use disorder (OUD). We implemented a hospitalist-led program, Project Caring for patients with Opioid Misuse through Evidence-based Treatment (COMET) to address gaps in care for hospitalized patients with OUD.

The coronavirus disease 2019 (COVID-19) pandemic has had harmful effects on the opioid epidemic. While a negative effect was predicted, we report on this reality in the hospital setting. We have seen a sharp rise in hospitalized patients with opioid use disorder (OUD). Our data should encourage ongoing efforts to reduce barriers in accessing medications for treatment, harm reduction interventions and additional education for trainees, primary care providers, and hospitalists alike. In the current climate, these interventions are critical to save the lives of patients with OUD.

Hospitalist teams have been on the frontlines in caring for patients with SARS-CoV-2. The uncertainties in caring for patients infected with the virus, rapidly changing clinical practice models and policies, surging patient volumes, and the isolation required for safe patient care, have placed unusually high stress on hospitalists. Well-being efforts aimed at supporting these teams have been critical to maintaining hospitalist resilience; however, despite intense scrutiny, little is known about the best methods to support the well-being of frontline hospitalists during this unprecedented and highly stressful time, a situation exacerbated by the severe limitations on social interactions. The authors engaged in an innovative endeavor at Duke University Hospital in Durham, North Carolina, to improve connections among hospitalists, even in the face of these limitations.