This article focuses on microspheres, types, preparation and their applications in drug delivery system. based on recent literatures. The microspheres are used for drug delivery that offers a potent therapeutic substitute for traditional or immediate-release single-unit dose forms. Microspheres are solid objects with diameters ranging from 1 to 1000µ m. The numerous types of microsphere are employed in the delivery of medications. The efficacy and administration strategies of the variously produced microspheres differ from those of standard dose forms. The microsphere is evaluated using a variety of methods that analyse the microsphere's quality. Finally brief summary of the current difficulties in processing these microspheres, which calls for additional study and development, is offered in the end.