Introduction: Stress is a part of life that is considered one of the great pandemics of the 21th century. At work, stress can affect health, personal well-being and job satisfaction, and in severe cases can trigger burnout syndrome. Factors that cause burnout including personal factors, workload excessive, and the quality of the work environment that do not support. Methods: This research uses literature study design from an international database, namely PubMed with the keywords used "burnout", "health workers", and "cross sectional". Result and Discussion: There have been 1942 journals in the last 10 years. After that, the year of publication and language screening were carried out in 399 journals, then the researchers identified screening titles, abstracts, and complete copies of 46 journals and selected accordingly with the inclusion criteria so that 13 articles will be reviewed in this literature review. Conclusion: It was found that burnout has a negative impact on health services as well as on the quality of life of health workers.