Dengue Hemorrhagic Fever (DHF) is a disease caused by dengue virus. DHF is mediated by the mosquito vector, the Aedes mosquito. The proliferation of dengue vector is influenced by many factors, one of which is climate factors. DHF is one of the main public health problems in Indonesia. Cases of dengue were first discovered in 1968 in the city of Jakarta and Surabaya. Currently Surabaya is one of the dengue endemic areas in Indonesia. . The case of DHF in the city of Surabaya can be said to be still quite high compared with another city in Indonesia, although there is a decrease in the number from year to year. When examined, many factors influence the high number of dengue cases in Surabaya, one of which is climate factor. Climate factors play a role in the proliferation of DHF vectors. Therefore, this study aims to examine for 10 years, namely in 2007 - 2017 whether there is a correlation between climate factors with dengue cases in the city of Surabaya., which in this study the climate factors used are rainfall, average temperature, and average air humidity. This research uses an analytical method namely Spearman on the SPSS software version 20. The results obtained that the case of DHF in the city of Surabaya has no relationship with climatic factors such as rainfall and average temperature with a significance value of the relationship p> 0.05. While the climate factor that has a relationship with DHF cases in Surabaya City is air humidity with a significance value of p <0.05 and has a positive relationship with the value of r = + 0.190. It can be concluded that not all climate factors have a relationship with the DHF case in Surabaya in 2007 - 2017, which has a relationship with the DHF case is air humidity.

Highlights: 1. There are differences in the result of the use of glucosamine and the increase of intraocular pressure.2. There are many other factors that may contribute to the increase in the intraocular pressure other than the use of glucosamine such as races, genetics, different dose, and duration of glucosamine use. Abstract: Background: Glucosamine is an amino monosaccharide that can directly stimulate the synthesis of glycosaminoglycans in the cartilage. It has been widely used as an osteoarthritis treatment. However, several literatures show the possible side effects of glucosamine, such as increased intraocular pressure (IOP). Objective: The objective of this study was to determine if there was any correlation between the use of glucosamine and the increase in IOP. Material and Method: This was a descriptive qualitative study that implied a systematic review design. The study sample consisted of patients with osteoarthritis (OA) and glaucoma in Iran, Indonesia, Thailand, the USA, and India between 2013 and 2018. The literature search was conducted on a database (PubMed and Google Scholar) and selected using inclusion and exclusion criteria. Discussion: The research identified 5 studies on the use of glucosamine and the increase of IOP. Two articles provide significant results on the correlation between the use of glucosamine and the increase of IOP (P < 0.05). In addition, two studies showed significant IOP reduction outcomes after discontinuation of glucosamine (P < 0.05). A case series indicated an increase in IOP during the 6th month of glucosamine use but still at normal value. Conclusion: Many other factors contribute to IOP growth, other than the use of glucosamine. Therefore, a large-scale randomized clinical trial or a multicentre cohort study using the same parameters is still needed to improve the quality of the subsequent systematic review