Background: In the modern broiler industry, leg and gait disorders are considerable problems. Fast-growing broilers are especially susceptible to bone abnormalities, causing major problems for broiler producers. Strontium ranelate (SrR) has been used successfully for the treatment of osteoporosis in humans. In addition, cerium oxide (CeO) is an anti-stress agent applied in the biological system.Methods: This study was conducted to investigate the effect of SrR, CeO, and their combinations on tibia quality in broilers. A total of 384 one-day-old Ross chicks were divided into six treatments, with four replicates per treatment (16 birds per replicate).The control group was fed a standard diet, and other groups were fed SrR at levels 450, 900 mg/kg feed, CeO at levels 300 and 600 mg/kg feed and a combination of 450 SrR + 300 CeO mg/kg feed. Bone mineral density (BMD), bone mineral content (BMC), bone strength (BS), tibia area, tibia weight, bone Length, bone diameter, minerals in tibia bone of male broilers, alkaline phosphatase gene (ALP) and osteocalcin gene (OC) in male broilers were analysed.
Results:The results showed that the addition of SrR and CeO had no significant influence (p > 0.01) on BMD, BMC, BS, bone weight, bone length and bone diameter. While there was a significant interaction between sex and treatments, especially in the combination group, BS in females significantly (p < 0.01) increased compared to the control group. Generally, females were found to be more responsive to treatments than males.Significant increases in gene expression were noticed in OC with the addition of low levels of SrR and CeO and mixed group compared to the control. The gene expression of ALP was increased significantly only in a combination group compared to the control group.
Conclusion:It is concluded that SrR and CeO can be used as beneficial additives in the feed to improve the tibia quality of broilers.
Minerals are used widely as feed additives in the diets of poultry to enhance bone and egg quality and productivity. Therefore, the current study aimed to evaluate the impact of strontium ranelate and cerium oxide addition in the diet on egg production and eggshell quality in laying hens. In this experiment, a total of 240 laying hens at the age of 44 weeks old, were divided into six treatments, with four replicates per treatment (10 hens per replicate). The hens were fed a standard diet for five weeks as an introductory period of preparation. The design of the dietary treatments was formulated as: control (T1) basal diet, Strontium ranelate (SrR) 400 and 800 mg/kg in basal diet (T2 and T3), Cerium oxide (CeO) 250 and 500 mg/kg in basal diet (T4 and T5) and their combination 400 mg/kg of Strontium ranelate + 250 mg/kg of Cerium oxide (T6) in the basal diet. Laying hen’s performance and, egg quality (eggshell strength, eggshell thickness, eggshell percentage, minerals in eggshell, yolk index and Haugh unit), were analyzed. The results showed that the addition of SrR and CeO did not affect performance, yolk index, Haugh unit, ratio of Ca, P, and Ce in the eggshell. However, supplementing 800 mg/kg SrR significantly increased eggshell strength, thickness, percentage, Sr in the eggshell compared to the control, while supplementing 250 or 500 mg/kg CeO significantly increased eggshell strength and thickness. The combination of SrR and CeO significantly increased eggshell strength compared to the control group. In conclusion, supplementing SrR (800 mg/kg) and CeO significantly improved the quality of the eggshell.
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