Phytal proteins are of great importance as they exhibit unique characteristics as immune modulators. Zingiber zerumbet family plants are used in various ways, including as food, beverages, and ornaments. The metabolites and extracts of these plants indicated an anti-viral, anti-cancer, anti-diabetic, and anti-inflammatory therapeutic characteristics features. Rheumatoid arthritis (RA) is an auto-immune condition that causes joint inflammation and malformations. The up- and down-regulation of certain rheumatoid arthritis proteins result in serious side effects. Ayurveda and other naturopathy treatments offer relief to a certain extent, while other pharmaceutical therapy is topical and temporary. The current study is aimed to comprehend the interaction of gamma-globulin proteins of RA patients with phytal proteins from leaves of the Zingiber zerumbet plant. The immunoassays, and MS orbitrap studies revealed the binding pattern and composition of the proteins. The protein- protein docking studies supported the method of binding pattern and these phytal proteins can be considered in the future for therapeutical or diagnostic purposes.