Brunner’s gland hyperplasia (BGH) or adenoma is an uncommon benign lesion which mimics malignancy in the duodenum. In the present study, five cases of BGH were reported, out of which one case was presented with large size measuring 5.54×4.05 cm, which has not been yet reported. Computed tomography demonstrated a large obstructing polypoidal mass, on esophagogastroduodenoscopy demonstrated polypoidal growth, and histologic examination revealed brunner’s gland adenoma. Most of the cases presented with gastric outlet obstruction and upper gastrointestinal bleeding with other non-specific symptoms. BGH is an uncommon benign condition of the duodenum, patients were usually asymptomatic or may present with non-specific symptoms or present as an incidental finding on endoscopy. Endoscopic and/or surgical resection represents the ideal approach. Brunner’s gland described by the Swiss anatomist Johann Conrad Brunner in 1688, predominantly present within the submucosa, begin just distal to the gastroduodenal junction, and gradually decrease in size and number distally and are often used as a histological marker of the duodenum. A Brunner’s gland adenoma (BGA), also known as BGH or hamartoma, is an uncommonbenign lesion in the duodenum.

Background: Fine needle aspiration cytology (FNAC) is becoming preoperative method of choice for diagnosis and management of various lumps and lesions since few decades. It helps clinician to decide mode of treatment in most cases in both non-neoplastic and neoplastic disorders. As cervical, axillary and inguinal lymphadenopathies are commonly encountered clinical problems, in this study, we evaluated the utility of FNAC for assessment of lymphadenopathy. Methods: This was a retrospective observational study done during the period between January 2016 to December 2019 in a private laboratory centre affiliated with private multispeciality hospital in Bhopal Madhya Pradesh. The FNAC procedure was done without radiological guidance for palpable lymph nodes of cervical, axillary, and inguinal regions. 10ml syringe and 23/24-gauge needles were used along with a plunger for FNAC procedure. Smears were made by standard smearing technique. Slides were stained with Papanicolaou (PAP), Lieshman and Giemsa stain and Diff-Quik methods. Ziehl-Neelson (ZN) staining for acid fast bacilli was done wherever required. Results: Total 128 cases of lymphadenopathy were assessed. Cervical lymph nodes were most commonly (77.3%) involved and reactive lymphadenitis (34.3%) was most common diagnosis on FNAC. Tubercular lymphadenitis was most common in young adults and reactive nonspecific lesions were most common in paediatric group. Metastatic carcinomas were most common after 50 years age group. Conclusions: Fine needle aspiration is simple, rapid and cost-effective method to know the cause of lymphadenopathy and also a reliable method to categorize the cause of lymphadenopathy into reactive, inflammatory, metastatic, and lymphoproliferative, avoiding the necessity of biopsy.