Objective To investigate the relationship between unexplained recurrent pregnancy loss (URPL) and polymorphisms of homocysteine metabolism-related genes in women. Materials and Methods A case–control study included 90 women with two or more consecutive unexplained pregnancy losses and 92 controlled women without miscarriage history; the female participants were in the age category of 18–35 years. The high-resolution melting technique was used to detect the single-nucleotide variants related to homocysteine metabolism disorder, namely MTHFR C677T, MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphism. Results The MTHFR C677T polymorphism had significantly correlation with URPL. Indeed, the frequency of the677T allele and genotypes (677CT, 677TT) in the URPL group was significantly higher than that in the control group (p < 0.05). However, the allele, as well as genotype distribution of MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphisms showed no significant difference (p > 0.05). MTHFR 677CT-1298AC genotype combination led to a 9.0-fold increased risk of URPL (OR 9.0; 95% CI, 2.25–35.99; p = 0.001), while the risk increased 10.0-fold (OR 10.0; 95% CI, 1.8–55.53; p = 0.008) when participants had more than the 3 variant loci. Conclusion The MTHFR C677T polymorphism was a risk factor for URPL, and determining the MTHFR C677T polymorphism had a potential prediction of URPL risk. Moreover, the MTHFR C677T and MTHFR A1298C joint mutants might have a synergistic effect on URPL. Conversely, there is a lack of evidence suggesting the URPL risk of MTHFR A1298C, MTR A2756G, and MTRR A66G polymorphisms.

Measles outbreaks still represents a serious public health problem in developingcountries. There are few reports of measles in pregnant women in the contemporaryliterature. The study aimed to describe clinical features subclinical findings andcomplications of hospitalized measles pregnancy women in Vietnam, in comparisonwith non-pregnancy women.All pregnant women hospitalized with measles at the National Hospital forTropical Diseases, Ha Noi, Northern Vietnam from July 2015 to June 2020 wereincluded. Demographic, clinical manifestations, laboratory findings, andcomplications data were analyzed.Of 98 hospitalized women, the mean time before the rash eruption and that ofsymptoms before hospital admission in the group of pregnant women were 3.5 and4.0 days, which were lower than those of the non-pregnant women group with 4.1and 4.8 days (p = 0.009 and p = 0.004, respectively). Measles rash in the pregnantwomen group was higher than that of the non-pregnant group with (87.8% vs.81.6%; p>0.05). The data of Koplic spot in pregnant women with measles was 34.7%and that of cough symptom was 85.7%. Corresponding in non-pregnant femalepatients were 28.6% and 83.7%, respectively (p < 0.05). The mean CRP value in thepregnant group was higher than that of the non-pregnant group (54.1 mg/L versus26.9 mg/L, p < 0.05). The percentage of pregnant women infected with measles withrespiratory complications was higher than that of no-pregnancy women (65.3% vs.44.9%, p = 0.042). The CRP value ≥ 94.5 mg/l was associated with pneumonia inpregnant women infected with measles (p<0.05; OR 31.2, 95% CI: 2.9 – 337.4).Pneumonitis was the most common complication in pregnant women withmeasles when compared to non-pregnant women. The level of CRP in combinationwith other subclinical findings was also a vital marker in predicting complications ofpregnancy with measles disease