The most frequent pregnancy issue is a miscarriage, which is defined as the spontaneous end of pregnancy before the fetus reaches viability. The current research aims to identify the potential significance of selenium (Se) and vitamin E (VE) as predictive diagnostic biomarkers in recurrent pregnancy loss (RPL). Methods: A case control study that included three study groups; 35 women with RPL, 30 non-aborted pregnant (NAP) women, and 25  healthy women. After rigorously applying the eligibility requirements, patients were chosen from those visiting Bint Al-Huda Teaching Hospital and Suq Al-Shuyukh General Hospital in Thi-Qar Province (Iraq). Serum VE and serum Se levels were determined using the ELISA and atomic absorption spectrophotometer techniques, respectively.  Results: The outcomes showed that the RPL group's serum VE and Se below normal levels were (88.6% and 62.9% respectively) lower than in the healthy control group (28% and 24% respectively). The level of VE was depleted in NAP group (93.3%) compared to HC group (28%) with significant differences, whereas the level of Se was significantly lower in RPL group (62.9%) compared NAP group (13.3%). Conclusions: A significant positive association of VE and Se in RPL and a significant negative association of VE and Se in NAP and HC. 

Background: RPL is a common early pregnancy complication that is characterized as three or more pregnancy losses occurring before the 20th week of gestation. RPL is a common early pregnancy complication that is characterized as three or more pregnancy losses occurring before the 20th week of gestation. Recurrent miscarriage (RM) is a common occurrence, affecting 15–25% of all pregnancies. The study's goal was to assess vitamin D, interleukin-17a, and interleukin-10 levels in women who had several miscarriages and investigate the relationship between biomarkers to determine the final outcome of pregnancy. Methods: A case control study that included three study groups; thirty five women with RPL, thirty non-aborted pregnant (NAP) women and twenty five apparently healthy women. Patients were selected from those attending Bint Al-Huda Teaching Hospital and Suq Al-Shuyukh General Hospital at Thi-Qar Province (Iraq) during the period between October 2021 and July 2022 after stringent application of the eligibility criteria. Serum samples was collected form each subjects and was evaluated for serum VD, IL-17A and IL-10 levels via enzyme-linked immunosorbent assay (ELISA). Results: The results revealed that serum VD and IL-10 levels in the RPL group were significantly lower than in the healthy control group (HC).