No abstract

The search for novel heterocyclic compounds with a natural product skeleton as potent enzyme inhibitors against clinical hits is our prime concern in this study. Here, a simple and facile two-step strategy has been designed to synthesize a series of novel coumarin-based dihydropyranochromenes ( 12a – 12m ) in a basic moiety. The synthesized compounds were thus characterized through spectroscopic techniques and screened for inhibition potency against the cytosolic hCA II isoform and β-glucuronidase. Few of these compounds were potent inhibitors of hCA II and β-glucuronidase with varying IC 50 values ranging from 4.55 ± 0.22 to 21.77 ± 3.32 μM and 440.1 ± 1.17 to 971.3 ± 0.05 μM, respectively. Among the stream of synthesized compounds, 12e and 12i were the most potent inhibitors of β-glucuronidase, while 12h , 12i , and 12j showed greater potency against hCA II. In silico docking studies illustrated the significance of substituted groups on the pyranochromene skeleton and binding pattern of these highly potent compounds inside enzyme pockets.

Efficient synthesis of novel coumarin-based pyrano-chromene derivatives.

Impact of blood pressure on dimple on chin was the objective of this study. Normal pressure of blood is crucial to life. Without the power that controls our blood to stream around the circulatory structure, no oxygen passed on through our tissues and organs. High pressure of blood also causes distinct syndromes. An estimate of 189 subjects partook in this survey. Subjects were undergraduate students in Bahauddin Zakariya University, Multan, Pakistan. Blood pressure was also examined by device. It was concluded from the survey that there was impact of systolic pressure of blood but there was no impact of diastolic pressure of blood on chin dimple.

In the title compound, C17H18BrN3O2S, the dihedral angle between the aromatic rings is 9.15 (17)°. A bifurcated intra­molecular N—H⋯(N,O) hydrogen bond generates two S(5) rings and a weak intra­molecular C—H⋯S inter­action completes an S(6) ring motif. In the crystal, inversion dimers linked by pairs of N—H⋯S hydrogen bonds generate R 2 2(8) loops and weak C—H⋯S and C—H⋯π inter­actions are also present.