Background: Hysterectomy is a commonly performed gynecological surgical procedure.It refers to the removal of the uterus, hysterectomy may involve a removal of the fallopian tubes and ovaries, it depends on all the reasons of the surgery and type of the procedure. Aim: The study intended to evaluate nurses' performance regarding the care of women undergoing hysterectomy and women satisfaction in Port Said hospitals. Design: A descriptive research was utilized. Sitting: Gynecological specialty hospital and El-Hayah Port Fouad. Subjects: The study subjects consisted of 50 nurses and 71 women undergoing hysterectomy. Tools: Data were collected by the use of three tools namely; Structured interview which included two parts; part 1: Personal characteristics of nurses or patients and part 2: questionnaire of nurses' knowledge regarding care of women undergoing hysterectomy, Observational checklist about nurses' practice regarding care of women undergoing hysterectomy ,and satisfaction scale regarding the care of women undergoing hysterectomy. Results: The vast majority of nurses had correct knowledge regarding care of pre-operative and post-operative care. Also, the majority of the women undergoing hysterectomy are satisfied regarding nursing care. Additionally, the satisfied practice was higher among studied nurses. Conclusion and recommendations: The nurses had an effective role towards care of women who undergoing surgical hysterectomy and able to provide practical advice on different issues regarding to health education advice and promotion. An educational program aimed at training nurses how to improve physical and psychological recovery of post-operative patients as rapidly as feasible.