Milk products are essential food in the human diet because it contains many essential trace minerals such as calcium, magnesium, copper, zinc, sodium, potassium and phosphorous. The utilization of, milk is increasing at a large scale throughout the world. It is essential to maintain the good quality of milk during production and manufacturing because the presence of toxic metals in the milk becomes the cause of health disturbance in human life. Therefore, the present investigation was carried out to determine concentrations of lead, nickel, iron, copper, and chromium in powdered milk and fresh milk products by Atomic Absorption Spectroscopy. Different milk samples of products (two fresh milks and two powdered milks) were purchased from the local market. For the decomposition of the organic substances in milk samples, wet digestion was used with a mixture of nitric acid and sulfuric acid in volume proportions 1:3 (v/v). The analytical curve for all metals covered the linear range from 0.5 to 4.0 ppm with correlation coefficients higher than 0.9994. The limit of detection (LOD) for Pb, Ni, Fe, Cu, and Cr were found to be 0.25, 0.023, 0.012, 0.0067, and 0.073 ppm, respectively. While the limit of quantification (LOQ) in the range of 0.02 to 0.76 ppm. Of all the metals determined, Pb, Ni, and Fe were the most abundant with concentrations between 1.233 and 1.677 ppm while Cr was not detected in all the samples. The results showed that fresh milk samples have a higher concentration of heavy metals compared to powdered milk samples.

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The synthesis of chalcone has drawn tremendous interest over the past years due to its wide applications in the pharmaceutical and biological sectors. Indeed, this compound is reported to possess a broad spectrum of promising bioactivities, including anti-inflammatory, anti-invasive, antioxidant, antitumor and antibacterial properties. In this work, chalcone 3 was synthesised via Claisen-Schmidt condensation by using a common starting material of benzaldehyde 1 and acetophenone 2 in the presence of alcoholic alkaline base. Subsequently, 3,5-diphenyl-2-pyrazoline 4 intermediate was successfully synthesised by reductive amination reaction of 3 with hydrazine hydrate. Thereafter, insertion of acyl subunit at N-1 position of the corresponding amine via 1N-acylation reaction afforded the targeted 1-acetyl-3,5-diphenyl-1H-pyrazole 5 derivative. The structures of all the synthesised compounds were confirmed by elemental analyses, IR, GC-MS and NMR spectra.

Muntingia calabura has a high phytochemical content, especially the phenolic group that can act as antioxidant. In Malaysia country, this M. calabura also known as ‘kerukup siam’ or ‘Ceri Kampung’ and it belongs to Muntingiaceae family. This research was conducted to determine the potential of antioxidant activity application of cherry leaves (M. calabura) from various solvent extracts (methanol, ethyl acetate, and n-hexane). The phytochemical contents were screening by using the established standard procedure. Total phenolic content (TPC) was determined according to the Folin-Ciocalteau colorimetric method, while the antioxidant activity was carried out using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical scavenging assay. Phytochemical screening on the leaves part methanolic extracts revealed that the presence of various biochemicals like flavonoids, phenols, steroids, triterpenes, tannins, reducing sugars, and saponins except the alkaloids. Among the three extracts, the methanol leaf extract gave the highest content of phenolics (8.20 mg GAE/g extract). Analyses of antioxidant activity with DPPH method showed that cherry leaf methanolic extracts produced high antioxidant activity with IC50 value of 167.70 mg/mL. The present study confirms that the presence of various phytochemicals which shows good antioxidant activity of M. calabura leaves. Therefore, it has the potential as a therapeutic antioxidant agent and can be used in cosmeceutical and food products.

Milk products are essential food in the human diet because it contains many essential trace minerals such as calcium, magnesium, copper, zinc, sodium, potassium and phosphorous. The utilization of, milk is increasing at a large scale throughout the world. It is essential to maintain the good quality of milk during production and manufacturing because the presence of toxic metals in the milk becomes the cause of health disturbance in human life. Therefore, the present investigation was carried out to determine concentrations of lead, nickel, iron, copper, and chromium in powdered milk and fresh milk products by Atomic Absorption Spectroscopy. Different milk samples of products (two fresh milks and two powdered milks) were purchased from the local market. For the decomposition of the organic substances in milk samples, wet digestion was used with a mixture of nitric acid and sulfuric acid in volume proportions 1:3 (v/v). The analytical curve for all metals covered the linear range from 0.5 to 4.0 ppm with correlation coefficients higher than 0.9994. The limit of detection (LOD) for Pb, Ni, Fe, Cu, and Cr were found to be 0.25, 0.023, 0.012, 0.0067, and 0.073 ppm, respectively. While the limit of quantification (LOQ) in the range of 0.02 to 0.76 ppm. Of all the metals determined, Pb, Ni, and Fe were the most abundant with concentrations between 1.233 and 1.677 ppm while Cr was not detected in all the samples. The results showed that fresh milk samples have a higher concentration of heavy metals compared to powdered milk samples.