Background : Nerve growth factor is a member of a group of proteins called Neurotrophins (NTs), which are necessary for growth and differentiation of neurons in both central and peripheral nervous systems. In addition to this essential role, NGF has been suggested to play a possible role in ovarian functions. Thus, we proposed this study to evaluate the nerve growth factor level in the follicular fluid of women with polycystic ovary syndrome undergoing Intracytoplasmic sperm injection (ICSI) in comparison with the control group (non-polycystic women).Results : Follicular fluid nerve growth factor levels of non PCOS women were significantly higher than these of PCOS group (245.399 ± 63.41pg/ml vs. 149.592 ± 64.86 pg/ml), p-value =0.0001*. Also, it was significantly correlated negatively with oocytes number (Correlation Coefficient r= -0.431, P-value = 0.01) and positively with FSH (r=0.370, p value = 0.029). Conclusion:Nerve growth factor level in the follicular fluid of polycystic ovary syndrome women is lower than it in non-PCOS ones. Additionally, it correlates directly with cycle day two FSH and inversely with oocytes number.