Background and objective The incidence of post-surgical complications (PSCs) after curative resection of non-metastatic colorectal cancer (CRC) is very widespread and evident. Some studies suggest that PSCs often predict poor long-term oncological outcomes. However, the available data on the topic is often controversial. The aim of this systematic review and meta-analysis was to study the effect of postoperative complications (POCs) on long-term oncological outcomes following curative resection of non-metastatic (stage I-III) CRC. Methods A comprehensive search of MEDLINE® and Excerpta Medica dataBASE (EMBASE) databases was performed via the Ovid platform, by using controlled vocabulary as well as natural language terms for POCs, outcomes, and CRC. Two authors independently screened the studies and extracted data. Conflicts were resolved by discussion among authors and also independently with the help of a third author. Meta-analysis was performed using a random-effects model (REM) to calculate pooled estimates for overall survival (OS), disease-free survival (DFS), and overall recurrence. Results Overall, 3,836 studies were initially screened, and 16 studies involving 37,192 patients were ultimately selected for final inclusion in the analysis. Meta-analysis of these studies showed that PSCs following non-metastatic CRC surgery predicted worse OS rates [hazard ratio (HR): 1.36; 95% CI: 1.15-1.61; p<0.00001], DFS (HR: 1.41; 95% CI: 1.11-1.80; p<0.00001), and overall recurrence (HR: 1.19; 95% CI: 1.04-1.37; p=0.01). Conclusion Based on our findings, PSCs predict poor OS rates, DFS, and overall recurrence following curative resection of non-metastatic CRC.

Introduction: Liver is the most common site for intra-abdominal abscess. Pyogenic liver abscess is more common in men compared to women. Risk factors include diabetes mellitus and chronic hepatobiliary disease. Alcohol abuse is known to cause bone marrow suppression and compromised immune system. Limited data are available regarding clinical outcomes in patients with history of alcohol use disorder who are admitted with pyogenic liver abscess. Methods: Using National Inpatient Sample databases from 2016 to 2019. We identified patients presenting with pyogenic liver abscess, the population were then divided based on the presence and absence of alcohol use disorder using appropriate ICD-10-CM/PCS codes. STATA 16.0 software was used for the analysis. Pearson's Chi-Square test was used to analyze categorical variable, whereas the student t-test was used to analyze continuous variables. Univariate and multivariate logistic regression was used to adjust for potential confounders. Primary outcome was in hospital mortality due to Pyogenic liver abscess in patients with alcohol use disorder. Results: Amongst total of 19,830 patients admitted with pyogenic liver abscess, 1,090 patients had history of alcohol use disorder and 18,740 patients did not. Both groups consisted predominantly of white male patients. Mean LOS was higher in alcohol use disorder group (866.08 days) than in non-alcohol use disorder group (7.3566.34 days ) (P5, 0.001 ). Mean total hospitalization charges were higher in AUD group ($ 20,968) than in the non-AUD group ($ 18,994) (P5 , 0.001) Conclusion: Patient with Pyogenic liver abscess with alcohol use disorder history had higher resource utilization, but less odds of mortality. (Table )

No abstract

No abstract

No abstract