Digital entrepreneurship is becoming more popular, so now is a great time to learn more about it. This research aims to find out how digital entrepreneurship knowledge in Vocational High School Students. The novelty of this present study is that it looks at digital entrepreneurship using a mixed-methods and focuses on Vocational High School Students as its subject. The sample used was twelve student respondents who had met the saturation criteria in the qualitative phase; from the results of the qualitative phase, several themes came up from the interview process using inductive code on the thematic analysis. However, the researchers only focused on the digital entrepreneurship theme based on the need for this theme at the vocational high school level. Then, the quantitative phase investigates in deep of other data and is processed using questionnaires. The result begins with a validity test in which R calculates each indicator its value above the table R-value of 0.576, while for the test the reliability of Cronbach’s Alpha value 0.966 has high reliability. Furthermore, using the Kolmogorov-Smirnov normality test found the data was normally distributed and homogeneous. Independent Sample t Test is known that there is a difference in digital entrepreneurship knowledge between Male and Female Students.