Aim: Assessing the needs and experiences of re-entering nurses during the COVID-19 pandemic. Background: During the COVID-19 outbreak in the Netherlands, thousands of former nurses have returned to nursing to support healthcare staff. After a period of absence and with little time to prepare, these former nurses re-entered during a challenging, uncertain and rapidly evolving pandemic. Little is known about the experiences and needs of these re-entering nurses. Design: Qualitative study Methods: We conducted semi-structured interviews with 20 purposively selected nurses who had re-entered nursing during the first wave of the COVID-19 pandemic in the Netherlands. Interviews were transcribed verbatim and analysed via thematic content analysis. This study followed the COREQ guidelines. Results: Participants mentioned that a lack of a clear job description led to unclarity about the kind of tasks that re-entering nurses were expected and allowed to perform. This unclarity was especially notable in the newly established COVID-19 departments. Re-entering nurses mentioned to wish for an easily accessible mentorship structure and an individualised and practical training program. Re-entering nurses felt supported by a positive team dynamic, which was shaped by the sense of urgency and relevance of their work and helped them deal with stressful experiences. Conclusion: The results indicate that a rapid and safe return to nursing during a pandemic could be facilitated by: a clear description of roles and responsibilities; an individualised assessment determining the competences and knowledge disparities of re-entering nurses; practical training focussing on competencies needed during a pandemic; and a collaborative mentorship structure to guide re-entering nurses. Relevance to clinical practice: The rapid recruitment of former nurses to mitigate an acute shortage of qualified nurses could play a vital role during a pandemic. To deploy these nurses effectively, safely and sustainably, it is important to address the needs of these re-entering nurses.