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SUMMARYImproving quality of healthcare for people with chronic conditions requires informed and knowledgeable healthcare providers and patients. Decision support and clinical information system are two of the main components to support improving chronic care. In this paper, we describe an ontology-based information and knowledge management framework that is important for chronic disease care management. Ontologybased knowledge acquisition and modeling based on knowledge engineering approach provides an effective mechanism in capturing expert opinion in form of clinical practice guidelines. The framework focuses on building of healthcare ontology and clinical reminder system that link clinical guideline knowledge with patient registries to support evidenced-based healthcare. We describe implementation and approaches in integrating clinical reminder services to existing healthcare provider environment by focusing on augmenting decision making and improving quality of patient care services. key words: ontology-based knowledge management, knowledge-based decision support, clinical information system

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SUMMARYThis paper presents a framework of supporting system for a drug formulation. We designed ontology to represent the related knowledge for reusable and sharing purposes. The designed ontology is applied with operation rules to suggest an appropriate generic drug production based on information of original drug. The system also provides a validation module to preliminarily approve a pharmaceutical equivalence of the suggested result. Preliminary testing with four random samples shows potential to reformulate a generic product by returning a satisfactory and acceptable of the system suggestions for all samples.