Digitally created online celebrities (so-called virtual influencers) have appeared on various social media and video streaming platforms. While the scientific community has recently started to take an interest in this new phenomenon, it still remains mostly unclear how online audiences engage with—and relate to—these artificial digital creations. To address the identified research gap, we conducted a preregistered experiment ( N = 179), comparing viewers’ parasocial interactions (PSIs) with either a human or a virtual influencer. Based on natural stimuli, we find that viewers’ parasocial response does not differ significantly between the two groups. However, by focusing on several theoretically relevant mediator variables, we uncover two opposing effects at play: While a significant direct effect signifies stronger PSIs with the virtual influencer, participants also attribute this persona with less mental human-likeness and similarity to themselves—which ultimately suppresses the observed advantage. Potential explanations for our results are discussed.