Background and Objective: The aging process in women is still a problem, especially in developing countries that will become developed countries, including Indonesia. Here, we investigated the action of Michelia champaca L. extract administration on antioxidant modulation to inhibit hippocampal apoptosis in middle-aged female rats. Materials and Methods: Thirty-two female Wistar rats were divided into four groups (n = 8 each group): the middle-aged rats without any treatment (control group) and three M. champaca L. extract groups (treated at doses of 100, 200, or 300 mg/kg b. w). The superoxide dismutase (SOD) levels and Bax and Bcl-2 expressions in the hippocampal region were analyzed using the technique of enzyme-linked immunosorbent assay. Results: The second and third doses of M. champaca L. extract significantly increased the SOD hippocampal levels compared with the control (P < 0.05). This extract also decreased Bax expression (at the second and third doses) and significantly increased Bcl-2 expression (at the highest dose) than that of the control (P < 0.05). Conclusions: The ethanol extract of M. champaca L. could modulate SOD and regulate apoptotic-related proteins in middle-aged female rats. Thus, the extract of M. champaca L. can be an alternative to prevent the degeneration of hippocampus due to the aging process.

Background: The goal of this study is to see how elderly gymnastics affect blood pressure, plasma glucose levels, and total cholesterol levels in women over the age of 65. Objective: The purpose of this study is to look into the effects of gymnastics on changes in blood pressure, blood sugar levels, and total cholesterol levels in the elderly.. Methods: Thirty-four female elderly women were divided into two groups: those who received gymnastics and those who did not. For three weeks, regular gymnastics exercises were performed on a weekly basis. Blood pressure, plasma glucose levels, and total cholesterol levels were measured using standard techniques and methods. Results: When compared to controls, regular gymnastics exercise can significantly lower blood pressure ( p < 0.05). This decrease is also observed in total cholesterol levels ( p < 0.05). Conclusions: Elderly gymnastics was found to lower blood pressure and total cholesterol levels in the elderly. As a result, elderly gymnastics could be a viable option for preventing cardiovascular disease and metabolic syndrome.