Osteosarcoma is the most common primary malignancy of bone. Although outcomes of patients with osteosarcoma have improved since the introduction of chemotherapy, outcomes of metastatic or unresectable osteosarcomas are still unsatisfactory. To improve osteosarcoma outcomes, the development of novel systemic therapies for osteosarcoma is needed. Since the 1880s, various immunotherapies have been utilized in patients with osteosarcoma and some patients have shown response to the treatment. Based on recent studies about the role of the immune system in malignancies, immunotherapies including immune modulators such as interleukin-2 and muramyl tripeptide, dendritic cells, immune checkpoint inhibitors, and engineered T cells have been utilized in patients with malignancies. Although there are limited reports of immunotherapies for osteosarcoma, immunotherapy is thought to be a promising treatment option for treating osteosarcomas. In this review, an overview of various immunotherapies for osteosarcoma is provided and their potential as adjuvant therapies is discussed.

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Background Context

For spinal fusion or the correction of spine deformity at multiple levels, intraoperative rod contouring is required to realign the spine. A French bender is the most common contouring tool used. There are several reports on the mechanical properties of various rods with manufactured straight rod; however, few reports describe the changes in a rod's mechanical properties after rod contouring. The authors investigated the influences of rod contouring on rod strength and stiffness. A 3-point bending test was conducted. Each 18-cm rod was loaded at a rate of 10 mm/min with a load applicator. Three different rod diameters (5.5, 6.0, and 6.35 mm) and 2 types of materials (titanium [Ti] alloy and cobalt-chromium [CoCr] alloy) were assessed. Different rod curvatures were evaluated: (1) a no-preparation rod of 0° (control); (2) a 0° rod bent at one point to make tangential angles of 10° and then bent back from the opposite side; (3) a bent rod with tangential angles of 20°; and (4) a 40° bent rod. The yield strength in all types of rod materials and diameter decreased after rod contouring using a French bender. The extent of decrease depended on the degree of bend. The bending stiffness of each rod also decreased. The CoCr rod showed higher bending stiffness than the Ti rod of the same diameter. Rod contouring using a French bender reduced the yield strength and stiffness in all types of rods. Decrease of yield strength correlated to the degree of bend. In the comparison of 20° and 40° contoured rods, the 6.0-mm CoCr rod showed the highest reduction force. This study found that rod contouring procedures reduced rod yield strength and stiffness.

Study Design:Retrospective cohort study.Objectives:To identify prevalence of ossification of the posterior longitudinal ligament (OPLL) of the cervical spine in a large sample, to characterize spinal involvement, and to identify associations with patient characteristics.Methods:Computed tomography (CT) scans of all patients receiving cervical spine CT imaging in a level-1 emergency department from January 1, 2014 to December 31, 2014 were reviewed. Diagnosis and classification of OPLL was performed, and data for associated patients was obtained (age, sex, race, ethnicity, body mass index, diabetes). US Census data was referenced for the sample population. Statistical analysis included t test and chi-square testing, with significance cutoff P < .05.Results:There were no significant differences between the sample and population data. Of 2917 patients reviewed, 74 exhibited OPLL (2.5%). Age distribution between OPLL and non-OPLL cohorts was significantly different (P < .01), with highest prevalence of OPLL between ages 40 to 49 and 50 to 59 years. Comorbid diabetes also differed between groups (27% OPLL, 13% non-OPLL, P < .01). There was no difference in distribution of sex, race, or ethnicity. For OPLL, segmental type is most common (67.6%), involving on average 3.4 levels. OPLL involvement begins at any level, but ends most commonly at C6 (40.5%) or C7 (36.5%). Among OPLL patients, 18 (24.3%) demonstrated concurrent ponticulus posticus.Conclusions:This review of 2917 patients reaffirms previous data, with OPLL prevalence of 2.5%. In asymptomatic patients, incidental diagnosis is frequently seen as early as ages 40 to 49 years. OPLL is better characterized with a significant association with diabetes, segmental type being the most common, and the caudal extent typically involving C6-7 (77%).