Background. Epipodophyllotoxins, etoposide and teniposide, have been shown to be implicated in the development of acute myelogenous leukemia in patients treated for solid tumors or acute lymphoblastic leukemia. Etoposide has been shown to be an effective agent against Langerhans cell histiocytosis (LCH) and has gained wider use recently for first‐line and salvage chemotherapy in cases of systemic LCH. Methods. The authors report two patients with secondary acute promyelocytic leukemia (APL) with a t(15;17) abnormality after chemotherapy that included etoposide for the treatment of LCH. Results. Patient 1, a 6‐year‐old girl, had APL develop 11 months after cessation of therapy that included vinblastine, prednisolone, and etoposide (9600 mg/m2 in total dose) for LCH. Patient 2, a 3‐year‐old girl, had APL develop 9 months after cessation of therapy that included vincristine, methotrexate, prednisolone, cyclophosphamide (10,800 mg/m2), and etoposide (4800 mg/ m2) for LCH. Conclusions. The authors have experience with four patients treated with etoposide for LCH and suggest that there is a predisposition to secondary APL with t(15;17) for patients with LCH treated with etoposide. The authors warn against the imprudent use of etoposide as a first‐line therapy for LCH.

Mulberry leaf extract (MLE) has known as inhibits elevated postprandial blood glucose level in human. Then we conducted a randomized, double-blind placebo-controlled parallel-group trial to evaluate safety when a green tea containing MLE is consumed three times a day, every day for four weeks. The participants (n = 48) were randomly allocated into two groups, an MLE beverage group and a control beverage group. The subjects were instructed to drink either a 500 mL green tea containing 550 mg MLE or a 500 mL green tea not containing MLE, three times a day, every day, for four weeks. No adverse reactions were observed over the four weeks trial, and no difference in the incidence of adverse events between the groups. These findings demonstrate that the consumption of a green tea containing 550 mg MLE three times a day for four weeks is safe for healthy adults.

We used female students(junior high,high school,and college)and their parents as subjects and assessed the eating behavior of the parents and children by investigating the passing down of drinking behavir(in the broad sense),preferences and drinking behavior (in the narrow sense:drinks or does not drink beverages),food habits(skipping breakfast/between meal types),degree of obesity,awareness of obesity,symptoms,and number of bottles ingested,and the following results were obtained.1)Beverages often drunk by both parents and children consisted of green tea,oolong tea,and milk,while sweet beverages,i.e.,fruit juice beverages,lactobacillus beverages, coffee,black tea(suger added),cola,carbonated beverages,and isotonic beverages were drunk in the following order:mothersfather,2)sweet beverages and isotonic drinks,for junior high school students, high school students,and college students:child>father and mother,and in every instance the differences were significant.3)The results for the junior high school students showed that the parents and children drank several types of beverages within the home,and the proportion of all of the mothers who drank cola and black tea(with/without suger)at home because they enjoyed them was high.The beverages that were drunk by each of the age brackets at home and

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